gene

PSPN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSPN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Neurotrophic factor of the GDNF family promoting dopaminergic and motor neuron survival in neurodegenerative disease

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🧬 Gene Info

Gene Symbol	PSPN
Full Name	Persephin
Chromosome	19p13.3
Protein Family	GDNF family
Function	encodes a neurotrophic factor belonging to the GDNF (glial cell line-derived neurotrophic factor) family of proteins.
Primary Expression	most neurons that respond to GDNF family ligands
Molecular Weight	25 kDa
UniProt ID	[O60543](https://www.uniprot.org/uniprot/O60543)
Ensembl ID	ENSG00000163389
OMIM	602565
GeneCards	PSPN
Human Protein Atlas	PSPN
Multiple exons	Spanning approximately 2.5 kb of genomic DNA
Signal peptide	Sequence for secretory pathway targeting
Cysteine-rich domain	Conserved motif characteristic of the GDNF family
Associated Diseases	Parkinson's disease, ALS
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PSPN — Persephin

gene · 1535 words

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PSPN Protein — Persephin

protein · 2220 words

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Pathway Diagram

graph TD
    PSPN["PSPN"]
    neurodegeneration["neurodegeneration"]
    PSPN -->|"implicated_in"| neurodegeneration
    style PSPN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PSPN in their description or question text

No additional research found