protein 2,220 words KG: PSPNPROTEIN
Contents

PSPN Protein — Persephin

🔬 Protein Info
Gene SymbolPSPN
Full NamePersephin
AliasesPSPNPROTEIN
Chromosome19p13.3
Protein FamilyGDNF family
Functionencodes a neurotrophic factor belonging to the GDNF (glial cell line-derived neurotrophic factor) family of proteins.
Primary Expressionmost neurons that respond to GDNF family ligands
Molecular Weight25 kDa
UniProt ID[O60543](https://www.uniprot.org/uniprot/O60543)
Ensembl IDENSG00000163389
OMIM602565
GeneCardsPSPN
Human Protein AtlasPSPN
Cysteine knot motifthree disulfide bonds forming a stable core
Homodimerfunctional form is a disulfide-linked dimer
Associated DiseasesParkinson's disease, ALS
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (8)

4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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