protein

PROGRANULIN_PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PROGRANULIN_PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Progranulin Protein (PGRN)

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🔬 Protein Info

Gene Symbol	GRN
Full Name	Progranulin
Aliases	PROGRANULIN_PROTEIN
Function	is a secreted glycoprotein encoded by the GRN gene that functions as a crucial regulator of neuronal survival, lysosomal function, immune response, and synaptic plasticity.
Primary Expression	Neurons, Microglia, Macrophages, Epithelial cells
Subcellular Localization	Secreted, Lysosomes, Cytoplasm
Molecular Weight	63.5 kDa (full-length); secreted fragments: 6-25 kDa
Amino Acids	593 aa
UniProt ID	P28799
GeneCards	GRN
Human Protein Atlas	GRN
P-granulin (full-length)	Contains all 7.5 repeats
Granulin A-G	Individual repeats released by proteolytic cleavage
Paragranulin	Contains only the first four repeats
Associated Diseases	Frontotemporal Dementia, Amyotrophic Lateral Sclerosis, Alzheimer's Disease
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PROGRANULIN_PROTEIN — AlphaFold P28799 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Progranulin Protein (PGRN)

protein · 1828 words

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Pathway Diagram

graph TD
    PROGRANULIN_PROTEIN["PROGRANULIN_PROTEIN"]
    neurodegeneration["neurodegeneration"]
    PROGRANULIN_PROTEIN -->|"implicated_in"| neurodegeneration
    style PROGRANULIN_PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PROGRANULIN_PROTEIN in their description or question text

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