protein

PMP22 PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PMP22 PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for PMP22 Protein — Peripheral Myelin Protein 22

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🔬 Protein Info

Gene Symbol	PMP22
Full Name	Peripheral Myelin Protein 22
Chromosome	17p12
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Peripheral nervous system, Schwann cells
Molecular Weight	22 kDa
UniProt ID	P60265
NCBI Gene ID	537
Ensembl ID	ENSG00000109099
OMIM	601097
GeneCards	PMP22
Human Protein Atlas	PMP22
Associated Diseases	Neuropathy, Als, multiple sclerosis, ALS, Neuropathy, Als
Interactions	PMP22, Proteins
KG Connections	2 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PMP22 PROTEIN — AlphaFold P60265 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    PMP22_PROTEIN["PMP22 Protein"]
    PMP22_GENE["PMP22 Gene"]
    MYELIN_FORMATION["Myelin Formation"]
    SCHWANN_CELLS["Schwann Cells"]
    COMPACT_MYELIN["Compact Myelin"]
    CMT1A["Charcot-Marie-Tooth 1A"]
    HNPP["Hereditary Neuropathy with Pressure Palsies"]
    GENE_DOSAGE["Gene Dosage Imbalance"]
    PROTEIN_AGGREGATION["Protein Aggregation"]
    ER_STRESS["ER Stress Response"]
    AUTOPHAGY["Autophagy"]
    AXONAL_DEGENERATION["Axonal Degeneration"]
    PERIPHERAL_NEUROPATHY["Peripheral Neuropathy"]
    UNFOLDED_PROTEIN["Unfolded Protein Response"]
    DEMYELINATION["Demyelination"]

    PMP22_GENE -->|"regulates expression"| PMP22_PROTEIN
    PMP22_PROTEIN -->|"essential for"| MYELIN_FORMATION
    PMP22_PROTEIN -->|"localizes in"| SCHWANN_CELLS
    MYELIN_FORMATION -->|"produces"| COMPACT_MYELIN
    GENE_DOSAGE -->|"causes overexpression"| PMP22_PROTEIN
    GENE_DOSAGE -->|"leads to"| CMT1A
    PMP22_GENE -->|"deletion causes"| HNPP
    PMP22_PROTEIN -->|"misfolding triggers"| PROTEIN_AGGREGATION
    PROTEIN_AGGREGATION -->|"activates"| ER_STRESS
    ER_STRESS -->|"induces"| UNFOLDED_PROTEIN
    UNFOLDED_PROTEIN -->|"activates"| AUTOPHAGY
    CMT1A -->|"causes"| DEMYELINATION
    DEMYELINATION -->|"leads to"| AXONAL_DEGENERATION
    AXONAL_DEGENERATION -->|"results in"| PERIPHERAL_NEUROPATHY

    style PMP22_PROTEIN fill:#1a3a4a,stroke:#4fc3f7
    style AUTOPHAGY fill:#1a3a2a,stroke:#81c784
    style UNFOLDED_PROTEIN fill:#1a3a2a,stroke:#81c784
    style CMT1A fill:#3a1a1a,stroke:#ef5350
    style HNPP fill:#3a1a1a,stroke:#ef5350
    style PROTEIN_AGGREGATION fill:#3a1a1a,stroke:#ef5350
    style ER_STRESS fill:#3a1a1a,stroke:#ef5350
    style DEMYELINATION fill:#3a1a1a,stroke:#ef5350
    style AXONAL_DEGENERATION fill:#3a1a1a,stroke:#ef5350
    style PERIPHERAL_NEUROPATHY fill:#3a2a1a,stroke:#ffa726
    style PMP22_GENE fill:#2a1a3a,stroke:#ce93d8
    style GENE_DOSAGE fill:#2a1a3a,stroke:#ce93d8

Outgoing (1)

Target	Relation	Type	Str
Proteins	inhibits	protein	0.50

Incoming (1)

Source	Relation	Type	Str
PMP22	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PMP22 PROTEIN in their description or question text

No additional research found