gene

PMAIP1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PMAIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PMAIP1 Gene

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🧬 Gene Info

Gene Symbol	PMAIP1
Full Name	Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PUMA)
Chromosome	18q21.32
Function	is a critical pro-apoptotic BH3-only protein that functions as a potent inducer of apoptosis.
Primary Expression	Ubiquitous; high expression in brain, especially in neurons
Amino Acids	193 aa
Pathways	NF-κB
UniProt ID	Q9BQZ9
NCBI Gene ID	5366
Ensembl ID	ENSG00000141682
OMIM	605426
GeneCards	PMAIP1
Human Protein Atlas	PMAIP1
Dopaminergic neuron apoptosis	PUMA is upregulated in response to α-synuclein toxicity and oxidative stress
Mitochondrial dysfunction	PUMA activation contributes to mitochondrial apoptosis in vulnerable dopaminergic neurons
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PMAIP1 — AlphaFold Q9BQZ9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PMAIP1 Gene

gene · 652 words

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NOXA Gene (PMAIP1)

gene · 1454 words

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Pathway Diagram

graph TD
    PMAIP1["PMAIP1"]
    neurodegeneration["neurodegeneration"]
    PMAIP1 -->|"implicated_in"| neurodegeneration
    style PMAIP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PMAIP1 in their description or question text

No additional research found