| Gene Symbol | PMAIP1 |
| Full Name | Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PUMA) |
| Chromosome | 18q21.32 |
| Function | is a critical pro-apoptotic BH3-only protein that functions as a potent inducer of apoptosis. |
| Primary Expression | Ubiquitous; high expression in brain, especially in neurons |
| Amino Acids | 193 aa |
| Pathways | NF-κB |
| UniProt ID | Q9BQZ9 |
| NCBI Gene ID | 5366 |
| Ensembl ID | ENSG00000141682 |
| OMIM | 605426 |
| GeneCards | PMAIP1 |
| Human Protein Atlas | PMAIP1 |
| Dopaminergic neuron apoptosis | PUMA is upregulated in response to α-synuclein toxicity and oxidative stress |
| Mitochondrial dysfunction | PUMA activation contributes to mitochondrial apoptosis in vulnerable dopaminergic neurons |
| Databases | GeneCardsHPASTRING |
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