gene

PIK3R2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3R2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

6Outgoing

3Incoming

0Experiments

0Debates

Summary

PI3K regulatory subunit beta gene involved in Akt signaling and neuronal survival

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🧬 Gene Info

Gene Symbol	PIK3R2
Chromosome	19q13.2
Protein Type	Gene
Function	of 724 amino acids
Amino Acids	724 aa
Exons	15
Pathways	PI3K, mTOR
GeneCards	PIK3R2
Human Protein Atlas	PIK3R2
SH3 domain	Located at the N-terminus, binds proline-rich regions and participates in protein-protein interactions
cSH3 domain	C-terminal SH3 domain with unique regulatory functions
Associated Diseases	Als, Thymic Epithelial Tumors
Interactions	EphA2
KG Connections	9 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PIK3R2 Gene

gene · 1441 words

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Pathway Diagram

flowchart TD
    PIK3R2(["PIK3R2"])
    Thymic_Epithelial_Tumors["Thymic Epithelial Tumors"]
    EphA2(["EphA2"])
    Als["Als"]
    PIK3CA(["PIK3CA"])
    AKT(["AKT"])
    AKT3(["AKT3"])
    PI3K(["PI3K"])
    neurodegeneration["neurodegeneration"]

    PIK3R2 -->|"associated with"| Thymic_Epithelial_Tumors
    PIK3R2 -->|"phosphorylates"| EphA2
    PIK3R2 -->|"associated with"| Als
    PIK3R2 -->|"associated with"| PIK3CA
    PIK3R2 -->|"associated with"| AKT
    PIK3R2 -->|"associated with"| AKT3
    PI3K -->|"associated with"| PIK3R2
    PIK3R2 -->|"implicated in"| neurodegeneration

    style PIK3R2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (6)

Target	Relation	Type	Str
Thymic Epithelial Tumors	associated_with	disease	0.80
EphA2	phosphorylates	protein	0.70
Als	associated_with	disease	0.65
PIK3CA	associated_with	gene	0.60
AKT	associated_with	gene	0.60
AKT3	associated_with	gene	0.60

Incoming (3)

Source	Relation	Type	Str
PI3K	associated_with	gene	0.60
AKT3	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PIK3R2 in their description or question text

No additional research found