Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PGAP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | PGAP2 |
| Full Name | Post-GPI Attachment to Proteins 2 |
| Protein Type | Enzyme |
| Function | encodes an essential enzyme involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors after their attachment to proteins in the endoplasmic reticulum. |
| Molecular Weight | 40 kDa |
| Ensembl ID | ENSG00000132581 |
| GeneCards | PGAP2 |
| Human Protein Atlas | PGAP2 |
| Glucosamine (GlcN) | Core sugar linking to phosphatidylinositol |
| Mannose (Man) residues | Three mannose units in the core |
| Phosphoethanolamine | Bridge to the protein C-terminus |
| Lipid moiety | Typically diacylglycerol or ceramide |
| Deacylation | Removes an acyl chain from the inositol ring |
| Acyl exchange | Replaces fatty acids to optimize membrane integration |
| Chain length selection | Prefers unsaturated long-chain fatty acids |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PGAP2["PGAP2"]
neurodegeneration["neurodegeneration"]
PGAP2 -->|"implicated_in"| neurodegeneration
style PGAP2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PGAP2 in their description or question text
No additional research found