gene

PDE11A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDE11A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

4Outgoing

1Incoming

0Experiments

0Debates

Summary

Comprehensive gene page for PDE11A, a dual-specificity phosphodiesterase with roles in cAMP/cGMP signaling, synaptic plasticity, and neurodegenerative disease.

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🧬 Gene Info

Gene Symbol	PDE11A
Full Name	Phosphodiesterase 11A
Chromosome	2q31.1
Function	The enzyme has a higher affinity for cGMP (Km ~100 nM) compared to cAMP (Km ~1 μM) [5].
Subcellular Localization	s and regulatory properties [3]. The enzyme has emerged as a potential therapeutic target for neurodegenerative diseases
Ensembl ID	ENSG00000128605
GeneCards	PDE11A
Human Protein Atlas	PDE11A
PDE11A1	Full-length enzyme with N-terminal regulatory domain
PDE11A2	Truncated isoform lacking the N-terminal domain
PDE11A3	Testis-specific isoform
PDE11A4	Brain and peripheral tissue isoform
Associated Diseases	Als, Sleep Duration
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PDE11A - Phosphodiesterase 11A

gene · 1223 words

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Pathway Diagram

graph TD
    PDE11A["PDE11A"]
    Als{"Als"}
    PDE11A -->|"associated with"| Als
    ALS{"ALS"}
    PDE11A -->|"associated with"| ALS
    GENES["GENES"]
    PDE11A -->|"associated with"| GENES
    AND["AND"]
    PDE11A -->|"associated with"| AND
    neurodegeneration["neurodegeneration"]
    PDE11A -->|"implicated in"| neurodegeneration
    GENES -->|"associated with"| PDE11A
    style PDE11A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Sleep Duration	associated_with	phenotype	0.90
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
GENES	associated_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDE11A in their description or question text

No additional research found