concept

OREXIN-A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OREXIN-A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

1Hypotheses

0Analyses

13Outgoing

1Incoming

0Experiments

0Debates

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💡 Concept Info

Name	OREXIN-A
Key Genes/Proteins	ERK, NF-κB, TLR4
Related Diseases	Insomnia

Pathway Diagram

graph TD
    OREXIN_A[OREXIN-A]
    OREXIN_A -->|binds| OX1R[OX1R]
    OREXIN_A -->|binds| OX2R[OX2R]
    OREXIN_A -->|regulates| Insomnia[Insomnia]
    OREXIN_A -->|inhibits| TLR4[TLR4]
    OREXIN_A -->|promotes| Seizures[Seizures]
    OREXIN_A -->|inhibits| ASTROCYTE[ASTROCYTE]
    OREXIN_A -->|attenuates| oxidative_stress[oxidative stress]
    OREXIN_A -->|attenuates| INFLAMMATION[INFLAMMATION]
    OREXIN_A -->|modulates| MICROGLIA[MICROGLIA]
    OREXIN_A -->|modulates| ASTROCYTES[ASTROCYTES]
    OX2R -->|binds| OREXIN_A

Outgoing (13)

Target	Relation	Type	Str
OX1R	binds	receptor	0.90
OX2R	binds	receptor	0.90
TLR4	inhibits	protein	0.85
Seizures	promotes	phenotype	0.85
Insomnia	regulates	disease	0.85
ASTROCYTE	inhibits	cell_type	0.80
oxidative stress	attenuates	process	0.80
INFLAMMATION	attenuates	process	0.80
MICROGLIA	modulates	cell_type	0.80
ASTROCYTES	modulates	cell_type	0.80
ASTROCYTES	inhibits	cell_type	0.70
ERK	inhibits	protein	0.70
NF-κB	inhibits	protein	0.70

Incoming (1)

Source	Relation	Type	Str
OX2R	binds	receptor	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Excess orexin-A worsens AD cognition through wake-driven amy	0.711	neurodegeneration	Orexin-A manipulation in AD cognition an

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OREXIN-A in their description or question text

No additional research found