gene

MS4A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MS4A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

3Outgoing

1Incoming

0Experiments

0Debates

Summary

MS4A2 encodes the beta subunit of the high-affinity IgE receptor (FcεRIβ), expressed in mast cells, basophils, and microglia. Genetic variants in MS4A2 are associated with Alzheimer's disease risk through immune modulation and neuroinflammatory pathways.

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🧬 Gene Info

Gene Symbol	MS4A2
Full Name	Membrane Spanning 4-Domains A2 (FcεRIβ)
Aliases	FcεRIβ
Chromosome	11q12.2
Protein Type	Receptor
Function	IgE receptor signaling, mast cell/basophil activation
Primary Expression	microglia, the resident immune cells of the central nervous system
Subcellular Localization	Plasma membrane: Primary localization as a transmembrane receptor component
Molecular Weight	26 kDa
Amino Acids	245 aa
Exons	7
UniProt ID	Q08431
NCBI Gene ID	2538
Ensembl ID	ENSG00000149507
GeneCards	MS4A2
Human Protein Atlas	MS4A2
Associated Diseases	Alzheimer's disease
KG Connections	4 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MS4A2 — AlphaFold Q08431 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MS4A2 Gene (FcεRIβ)

gene · 1520 words

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MS4A2 Protein

protein · 584 words

→

Pathway Diagram

graph TD
    MS4A2["MS4A2"]
    Ms{"Ms"}
    MS4A2 -->|"expressed in"| Ms
    Epigenetic(["Epigenetic"])
    MS4A2 -->|"expressed in"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    MS4A2 -->|"expressed in"| Dna_Methylation
    neurodegeneration["neurodegeneration"]
    MS4A2 -->|"implicated in"| neurodegeneration
    HIF1A["HIF1A"]
    HIF1A -->|"expressed in"| MS4A2
    style MS4A2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (3)

Target	Relation	Type	Str
Ms	expressed_in	disease	0.65
Epigenetic	expressed_in	pathway	0.60
Dna Methylation	expressed_in	pathway	0.60

Incoming (1)

Source	Relation	Type	Str
HIF1A	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MS4A2 in their description or question text

No additional research found