gene

MAPK12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

4Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for MAPK12

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🧬 Gene Info

Gene Symbol	MAPK12
Aliases	p38-gamma, ERK6, SAPK3
Chromosome	22q13.1
Protein Type	Kinase
Function	MAPK12 participates in multiple cellular signaling pathways
Primary Expression	various tissues, with particularly high expression in skeletal muscle and brain, where it regulates diverse cellular processes including cell differen
Molecular Weight	42 kDa
Amino Acids	182 aa
Pathways	Mapk, MAPK, mapk, MAPK pathway
GeneCards	MAPK12
Human Protein Atlas	MAPK12
Stress-Activated Kinase Pathway	MAPK12 is activated by cellular stresses including UV radiation, oxidative stress, and inflammatory cytokines (TNF-α, IL-1).
Cell Differentiation	MAPK12 plays roles in muscle cell differentiation and neuronal development.
Synaptic Plasticity	In neurons, MAPK12 is involved in regulating synaptic strength and plasticity, processes critical for learning and memory.
Inflammatory Responses	MAPK12 contributes to the production of inflammatory mediators in glial cells.
Associated Diseases	neurodegeneration
Interactions	App
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAPK12

gene · 659 words

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Pathway Diagram

flowchart TD
    MAPK12(["MAPK12"])
    Senescence["Senescence"]
    FOS(["FOS"])
    Mapk["Mapk"]
    App(["App"])
    neurodegeneration["neurodegeneration"]

    MAPK12 -->|"therapeutic target"| Senescence
    MAPK12 -->|"therapeutic target"| FOS
    MAPK12 -->|"therapeutic target"| Mapk
    MAPK12 -->|"activates"| App
    MAPK12 -->|"implicated in"| neurodegeneration

    style MAPK12 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
Senescence	therapeutic_target	disease	0.65
Mapk	therapeutic_target	pathway	0.60
App	activates	protein	0.60
FOS	therapeutic_target	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK12 in their description or question text

No additional research found