Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | MAP4 |
| Chromosome | 3p21.31 |
| Protein Type | Gene |
| Function | Microtubule-associated protein 4 (MAP4) is a cytoskeletal protein that binds to microtubules and regulates their stability, dynamics, and interaction with other cellular components. |
| Primary Expression | non-neuronal cells but is also present in neurons where it interacts with tubulin to promote microtubule assembly and protect aga |
| Molecular Weight | 210 kDa |
| Amino Acids | 1862 aa |
| UniProt ID | P27816 |
| GeneCards | MAP4 |
| Human Protein Atlas | MAP4 |
| Tau protein | Primary neuronal MAP with which MAP4 shares regulatory pathways |
| MAP2 | Classical neuronal microtubule-associated protein |
| Tubulin | Core microtubule component with which MAP4 directly interacts |
| GSK-3β | Kinase regulating MAP4 phosphorylation |
| Axonal transport | Critical process requiring MAP4-mediated microtubule stability |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MAP4["MAP4"]
neurodegeneration["neurodegeneration"]
MAP4 -->|"implicated_in"| neurodegeneration
style MAP4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MAP4 in their description or question text
No additional research found