gene

MAP2K5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP2K5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

0Debates

Summary

MAP2K5 (MEK5) - Mitogen-activated protein kinase kinase 5 that specifically activates ERK5, involved in neuronal development, synaptic plasticity, and neuroprotection. Key player in MAPK/ERK5 signaling pathway with implications for Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.

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🧬 Gene Info

Gene Symbol	MAP2K5
Aliases	MAP2K5 (MEK5)
Function	The MEK5 protein consists of 471 amino acids and contains a kinase domain with characteristic motifs required for dual-specificity phosphorylation.
Amino Acids	471 aa
Pathways	MAPK
Ensembl ID	ENSG00000108691
GeneCards	MAP2K5
Human Protein Atlas	MAP2K5
Growth factors	BDNF, NGF, EGF
Cellular stress	Oxidative stress, endoplasmic reticulum stress
Synaptic activity	Glutamate receptor activation
Inflammatory signals	Cytokine signaling in glia
MEF2 family	Myocyte enhancer factor 2 (MEF2A-D)
CREB	cAMP response element-binding protein
c-Fos	Immediate early gene product
Associated Diseases	neurodegeneration
Interactions	ALS
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MAP2K5

gene · 2781 words

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Pathway Diagram

flowchart TD
    MAP2K5(["MAP2K5"])
    Als["Als"]
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ALS(["ALS"])
    AMYOTROPHIC_LATERAL_SCLEROSIS(["AMYOTROPHIC LATERAL SCLEROSIS"])
    GENES(["GENES"])
    neurodegeneration["neurodegeneration"]

    MAP2K5 -->|"interacts with"| Als
    MAP2K5 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
    MAP2K5 -->|"interacts with"| ALS
    MAP2K5 -->|"therapeutic target"| AMYOTROPHIC_LATERAL_SCLEROSIS
    MAP2K5 -->|"therapeutic target"| GENES
    MAP2K5 -->|"implicated in"| neurodegeneration

    style MAP2K5 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
ALS	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAP2K5 in their description or question text

No additional research found