concept

LYC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

19Hypotheses

0Analyses

12Outgoing

0Incoming

18Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	LYC
Key Genes/Proteins	AKT, BECN1, MAP1LC3, PINK1, PRKN
Related Pathways	autophagy

Pathway Diagram

flowchart TD
    N0["LYC"]
    N1["AKT"]
    N0 -->|"inhibits"| N1
    N2["autophagy"]
    N0 -->|"activates"| N2
    N3["Renal Fibrosis"]
    N0 -->|"treats"| N3
    N4["Mitophagy"]
    N0 -->|"activates"| N4
    N5["BECN1"]
    N0 -->|"contributes to"| N5
    N6["MAP1LC3"]
    N0 -->|"contributes to"| N6

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 concept
    class N1 protein
    class N2 pathway
    class N3 disease
    class N4 process
    class N5 gene
    class N6 gene

Outgoing (12)

Target	Relation	Type	Str
Autophagy	activates	process	0.90
AKT	inhibits	protein	0.90
autophagy	activates	pathway	0.90
AKT	inhibits	protein	0.85
Renal Fibrosis	treats	disease	0.85
PINK1	upregulates	protein	0.80
PRKN	upregulates	protein	0.80
MAP1LC3	contributes_to	gene	0.80
BECN1	contributes_to	gene	0.80
Mitochondrial Membrane Potential	downregulates	phenotype	0.75
PINK1	regulates	gene	0.70
PRKN	regulates	gene	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (19)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Ne	0.740	neuroscience	Trans-synaptic tau spreading and propaga
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat	0.705	neurodegeneration	Perivascular spaces and glymphatic clear
Pharmacological EZH2 Inhibition Resets Polycomb-Mediated Rep	0.680	neurodegeneration	epigenetic reprogramming aging neurons
Metabolic Reprogramming via Microglial Glycolysis Inhibition	0.672	neurodegeneration	Synaptic pruning by microglia in early A
Glial Glycocalyx Remodeling Therapy	0.649	neurodegeneration	4R-tau strain-specific spreading pattern

Glycine-Rich Domain Competitive Inhibition	0.640	neurodegeneration	TDP-43 phase separation therapeutics for
Pharmacological Enhancement of APOE4 Glycosylation	0.622	neurodegeneration	APOE4 structural biology and therapeutic
Dual-Phase Medium-Chain Triglyceride Intervention	0.622	neurodegeneration	How do astrocyte-neuron metabolic intera
Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift	0.620	neuroinflammation	What molecular mechanisms mediate SPP1-i
Glycosaminoglycan Template Disruption Approach	0.597	neurodegeneration	Protein aggregation cross-seeding across
APOE4 drives astrocyte metabolic reprogramming toward glycol	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat
Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes	0.530	neurodegeneration	Comparative epigenetic signatures: DNA m
H4: Polycomb Repression Relaxes at Neurodevelopment Genes	0.530	neurodegeneration	Investigate mechanisms of epigenetic rep
Dysregulated microglial glycolysis via HIF1α activation shif	0.520	neurodegeneration	Synaptic pruning by microglia in neurode
Primed microglia occupy a hybrid high-glycolysis and high-re	0.510	neuroinflammation	Do microglia actually switch between gly
Sulfated glycans and metal-binding CSF proteins brace alpha-	0.489	neurodegeneration	Which specific CSF molecular components
DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Sca	0.460	neurodegeneration	Investigate mechanisms of epigenetic rep
Lactate-HCAR1 signaling maintains a self-reinforcing glycoly	0.427	neuroinflammation	Do microglia actually switch between gly
BMAL1-CLOCK regulation of miR-143/145 locks microglia into g	0.389	neuroinflammation	Do microglia actually switch between gly

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (18)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
TDP-43 mutant mouse model cGAS/STING pathway analysis	validation	amyotrophic lateral sclerosis	0.900	0.00	TDP-43 mutant mice	proposed	N/A
TDP-43 mitochondrial invasion and DNA release via mPTP	exploratory	amyotrophic lateral sclerosis	0.900	0.00	cultured cells	proposed	N/A
TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons	exploratory	Amyotrophic Lateral Sclerosis	0.900	0.00	iPSC-derived motor neurons	proposed	N/A
cGAS/STING pathway validation in TDP-43 mutant mice	validation	Amyotrophic Lateral Sclerosis	0.850	0.00	TDP-43 mutant mice	proposed	N/A
High fat diet aging study in CPT1A knockout mice	validation	kidney aging and metabolic dys	0.850	0.00	conditional CPT1A knockout mic	proposed	N/A
cGAMP biomarker analysis in ALS patient spinal cord samples	exploratory	Amyotrophic Lateral Sclerosis	0.800	0.00	Human ALS patient spinal cord	proposed	N/A
TDP-43 pathology prevalence and distribution in AD cases	exploratory	Alzheimer's disease	0.800	0.00	human postmortem brain tissue	proposed	N/A
E2F coordination of G2/M transcriptional program	exploratory		0.750	0.00	endocycling mammalian cells	proposed	N/A
Cognitive impact of TDP-43 pathology in AD patients	clinical	Alzheimer's disease	0.700	0.00	human patients	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$130,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Proposed experiment from debate on Microglia activate astrocytes via I	falsification	Neuroinflammation	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000
ALS Progression Rate Heterogeneity — mechanism and biomarker predictor	clinical	ALS	0.400	0.50	human	proposed	$6,550,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Saturation mutagenesis of twenty disease-associated regulatory elements at singl [PMID:31395865]	["Kircher M", "Xiong C", "Martin B", "Sc	Nature Communications	2019	267
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382]	Meneses A, Koga S, O'Leary J, Dickson DW	Mol Neurodegener	2021	2
Protein transmission in neurodegenerative disease. [PMID:32203399]	Peng C, Trojanowski JQ, Lee VM	Nat Rev Neurol	2020	2
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591]	Rusmini P, Cortese K, Crippa V, Cristofa	Autophagy	2019	2
Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-d [PMID:41520557]	Sun B, Zhang A, Feng S, Jamali AW, Jia Z	Int Immunopharmacol	2026	1
HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352]	Pesce NA, Seminara G, Giarrusso G, Tomas	Adv Biol (Weinh)	2026	1
Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285]	Fang M, Zhou Y, He K, Lu Y, Tao F, Huang	Mol Neurobiol	2025	1
Deficiency of Microglial Hv1 Protects Against Lipopolysaccharide-Induced Neuroin [PMID:40911376]	Sun L, Wang X, Guan S, Zhang P, Chen D,	FASEB J	2025	1
Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic sc [PMID:38448448]	Yang ZR, Suo H, Fan JW, Lv N, Du K, Ma T	Nat Commun	2024	1
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014]	Fontana F, Giannitti G, Marchesi S, Limo	Int J Biol Sci	2024	1
NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244]	Fei Y, Huang X, Ning F, Qian T, Cui J, W	Biomed Pharmacother	2024	1
AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated [PMID:39217289]	Zhou J, Zhang J, Xu F, Gao H, Wang L, Zh	Mol Med	2024	1
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in p [PMID:39149513]	Samaržija I, Lukiyanchuk V, Lončarić M,	Front Cell Dev Biol	2024	1
N protein of PEDV plays chess game with host proteins by selective autophagy. [PMID:36861818]	Zhai X, Kong N, Zhang Y, Song Y, Qin W,	Autophagy	2023	1
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. [PMID:36754049]	Hung ST, Linares GR, Chang WH, Eoh Y, Kr	Cell	2023	1
Hexokinase 2-mediated gene expression via histone lactylation is required for he [PMID:37463576]	Rho H, Terry AR, Chronis C, Hay N	Cell Metab	2023	1
Genetic regulation of post-translational modification of two distinct proteins. [PMID:35332118]	Landini A, Trbojević-Akmačić I, Navarro	Nat Commun	2022	1
Divergent Golgi trafficking limits B cell-mediated IgG sialylation. [PMID:35726710]	Glendenning LM, Zhou JY, Reynero KM, Cob	J Leukoc Biol	2022	1

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LYC in their description or question text

Glycine-Rich Domain Competitive Inhibition

Score: 0.640 · neurodegeneration · 2026-04-02

## Mechanistic Overview Glycine-Rich Domain Competitive Inhibition starts from the claim that modulating TARDBP within t

Pharmacological Enhancement of APOE4 Glycosylation

Score: 0.622 · neurodegeneration · 2026-04-02

## Mechanistic Overview Pharmacological Enhancement of APOE4 Glycosylation starts from the claim that modulating ST6GAL1

Dual-Phase Medium-Chain Triglyceride Intervention

Score: 0.622 · neurodegeneration · 2026-04-12

**Molecular Mechanism and Rationale** The dual-phase medium-chain triglyceride (MCT) intervention targets key enzymes i

Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift

Score: 0.620 · neuroinflammation · 2026-04-22

**Molecular Mechanism and Rationale** The SPP1 (secreted phosphoprotein 1, osteopontin)-HIF1α metabolic rewiring pathwa

Glycosaminoglycan Template Disruption Approach

Score: 0.597 · neurodegeneration · 2026-04-02

Heparan sulfate and other glycosaminoglycans serve as nucleation templates that facilitate cross-seeding by concentratin

APOE4 drives astrocyte metabolic reprogramming toward glycolysis via PGC-1α supp

Score: 0.580 · neuroscience · 2026-04-22

**Molecular Mechanism and Rationale** The APOE4-driven metabolic reprogramming of astrocytes represents a complex casca

Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes

Score: 0.530 · neurodegeneration · 2026-04-25

Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes

H4: Polycomb Repression Relaxes at Neurodevelopment Genes

Score: 0.530 · neurodegeneration · 2026-04-22

## Mechanistic Overview H4: Polycomb Repression Relaxes at Neurodevelopment Genes starts from the claim that modulating

Dysregulated microglial glycolysis via HIF1α activation shifts the balance from

Score: 0.520 · neurodegeneration · 2026-04-22

## Mechanistic Overview Dysregulated microglial glycolysis via HIF1α activation shifts the balance from neuroprotective

Primed microglia occupy a hybrid high-glycolysis and high-respiration metabolic

Score: 0.510 · neuroinflammation · 2026-04-21

## Mechanistic Overview Primed microglia occupy a hybrid high-glycolysis and high-respiration metabolic state starts fro

Sulfated glycans and metal-binding CSF proteins brace alpha-synuclein fibril pol

Score: 0.489 · neurodegeneration · 2026-04-25

Electrostatic bridging by glycans and low-abundance proteins preserves disease-relevant fibril architecture.

DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Scars' at Polycomb Targ

Score: 0.460 · neurodegeneration · 2026-04-21

## Mechanistic Overview DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Scars' at Polycomb Targets starts from

Lactate-HCAR1 signaling maintains a self-reinforcing glycolytic priming loop

Score: 0.427 · neuroinflammation · 2026-04-21

## Mechanistic Overview Lactate-HCAR1 signaling maintains a self-reinforcing glycolytic priming loop starts from the cla

BMAL1-CLOCK regulation of miR-143/145 locks microglia into glycolytic priming

Score: 0.389 · neuroinflammation · 2026-04-21

## Mechanistic Overview BMAL1-CLOCK regulation of miR-143/145 locks microglia into glycolytic priming starts from the cl