gene

LIMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

3Outgoing

3Incoming

0Experiments

0Debates

Summary

Lysosomal Integral Membrane Protein 2 - a receptor for glucocerebrosidase involved in Parkinson's disease

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🧬 Gene Info

Gene Symbol	LIMP
Full Name	2 Protein
Aliases	LIMP2
Chromosome	4q21.1
Function	The discovery that LIMP-2 mediates the mannose-6-phosphate-independent trafficking of GCase to lysosomes represented a paradigm shift in our understanding of lysosomal enzyme targeting.
GeneCards	LIMP
Human Protein Atlas	LIMP
Brain	Neurons, microglia, and oligodendrocytes
Kidney	Proximal tubules
Liver	Hepatocytes
Interactions	AND, LYSOSOME, RAB7A
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: LIMP2 — AlphaFold Q8N3U4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LIMP-2 Protein

protein · 1592 words

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LIMP2 Gene

gene · 827 words

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Pathway Diagram

flowchart TD
    LIMP2(["LIMP2"])
    Tumor["Tumor"]
    Leukemia["Leukemia"]
    RAB7A(["RAB7A"])
    AND(["AND"])
    LYSOSOME(["LYSOSOME"])
    neurodegeneration["neurodegeneration"]

    LIMP2 -->|"activates"| Tumor
    LIMP2 -->|"activates"| Leukemia
    LIMP2 -->|"activates"| RAB7A
    RAB7A -->|"activates"| LIMP2
    AND -->|"activates"| LIMP2
    LYSOSOME -->|"activates"| LIMP2
    LIMP2 -->|"implicated in"| neurodegeneration

    style LIMP2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
Tumor	activates	disease	0.65
Leukemia	activates	disease	0.65
RAB7A	activates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
AND	activates	gene	0.60
RAB7A	activates	gene	0.60
LYSOSOME	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LIMP2 in their description or question text

No additional research found