| Gene Symbol | KCND3 |
| Chromosome | 1p13.2 |
| Protein Type | Channel |
| Function | The Kv4.3 channel (encoded by KCND3) is a voltage-gated potassium channel that mediates transient outward current (Ito) in neurons and cardiac myocytes. |
| Primary Expression | the hippocampus, cortex, and cerebellum, where it regulates neuronal excitability, back-propagation of action potentials, and |
| Amino Acids | 636 aa |
| Exons | 16 |
| Ensembl ID | ENSG00000100285 |
| GeneCards | KCND3 |
| Human Protein Atlas | KCND3 |
| S1-S4 domains | Voltage-sensing domain that detects membrane depolarization |
| S5-S6 domains | The pore region responsible for K+ ion selectivity and conductance |
| N-terminal T1 domain | Tetramerization domain for subunit assembly |
| C-terminal regulatory domain | Contains binding sites for auxiliary subunits and post-translational modifications |
| Cerebellum | Purkinje cells and granule cells - critical for motor coordination |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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