Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL1B, TNFA, NLRP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C1QA, C3, CX3CR1, CX3CL1 | co_associated_with | gene | 0.40 |
| CLOCK, ARNTL | co_associated_with | gene | 0.40 |
| GPR43, GPR109A | co_associated_with | gene | 0.40 |
| HIF1A, NFKB1 | co_associated_with | gene | 0.40 |
| IGFBPL1 | co_associated_with | gene | 0.40 |
| DNMT3A, HDAC1/2 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cardiovascular-Neuroinflammation Crosstalk Interruption | 0.587 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Cerebrovascular function analysis in CD2AP mutant mice | validation | Alzheimer's disease | 0.900 | 0.00 | mice | proposed | N/A |
| Cell-cell interaction analysis of perivascular-microglial crosstalk | exploratory | Alzheimer's disease | 0.800 | 0.00 | AD mouse models | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Complement C1q-Targeted Microglial Membrane Camouflaged Nanolipid Carriers for S [PMID:41114949] | Ding YN, Li MQ, Ding PT, Wang P, Guan PP | Nano letters | 2026 | 1 |
| Systemic inflammation as a central player in the initiation and development of A [PMID:40841660] | Bayraktaroglu I, Ortí-Casañ N, Van Dam D | Immunity & ageing : I & A | 2025 | 1 |
| Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibi [PMID:40050873] | Ma J, Tian Y, Du C, Zhu Y, Huang W, Ding | Journal of nanobiotechnology | 2025 | 1 |
| Interactions between antidiabetes medications and heart-brain axis. [PMID:39639832] | Ong LT, Sia CH | Current opinion in endocrinolo | 2025 | 1 |
| The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Rev [PMID:40507911] | Popa E, Popa AE, Poroch M, Poroch V, Ung | International journal of molec | 2025 | 1 |
| Air pollution, glymphatic impairment, and Alzheimer's disease. [PMID:37777345] | Hussain R, Graham U, Elder A, Nedergaard | Trends in neurosciences | 2023 | 0 |
| Molecular biomarkers for vascular cognitive impairment and dementia. [PMID:37957261] | Hosoki S, Hansra GK, Jayasena T, Poljak | Nature reviews. Neurology | 2023 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.86 · 2026-04-12
closed · Rounds: 5 · Score: 0.95 · 2026-04-12
Hypotheses and analyses mentioning IL1B, TNFA, NLRP3 in their description or question text
No additional research found