concept

IGFBPL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGFBPL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections
9Hypotheses
2Analyses
14Outgoing
16Incoming
1Experiments
3Debates

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💡 Concept Info
NameIGFBPL1
Key Genes/ProteinsAPOE, C1QA, C1QA, C3, CX3CR1, CX3CL1, CLOCK, ARNTL, DNMT3A, HDAC1/2, GPR43, GPR109A
Related DiseasesAlzheimer's disease, neurodegeneration
Linked Hypotheses7 hypotheses
🔮 Predicted Structure: IGFBPL1 — AlphaFold Q9Y6Q9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    IGFBPL1[IGFBPL1]
    IGFBPL1 -->|regulates| Microglial_Homeostasis[Microglial Homeostasis]
    IGFBPL1 -->|inhibits| Microglial_Activation[Microglial Activation]
    IGFBPL1 -->|regulates| Metabolic_Reprogramming[Metabolic Reprogramming]
    IGFBPL1 -->|stabilizes| Anti_Inflammatory_Transcriptio[Anti-Inflammatory Transcriptional Programs]
    IGFBPL1 -->|regulates| microglial_homeostasis[microglial_homeostasis]
    IGFBPL1 -->|associated_with_microglial_priming| Alzheimer_s_disease[Alzheimer's disease]
    IGFBPL1 -->|co_associated_with| TNF_IL6[TNF/IL6]
    IGFBPL1 -->|co_associated_with| Multiple[Multiple]
    IGFBPL1 -->|co_associated_with| TREM2[TREM2]
    IGFBPL1 -->|co_associated_with| IL1B__TNFA__NLRP3[IL1B, TNFA, NLRP3]
    h_d4ff5555[h-d4ff5555] -->|targets| IGFBPL1
    C1QA__C3__CX3CR1__CX3CL1[C1QA, C3, CX3CR1, CX3CL1] -->|co_associated_with| IGFBPL1
    CLOCK__ARNTL[CLOCK, ARNTL] -->|co_associated_with| IGFBPL1
    GPR43__GPR109A[GPR43, GPR109A] -->|co_associated_with| IGFBPL1
    HIF1A__NFKB1[HIF1A, NFKB1] -->|co_associated_with| IGFBPL1
    APOE[APOE] -->|co_associated_with| IGFBPL1
    C1QA[C1QA] -->|co_associated_with| IGFBPL1
    DNMT3A__HDAC1_2[DNMT3A, HDAC1/2] -->|co_associated_with| IGFBPL1
    h_6880f29b[h-6880f29b] -->|targets| IGFBPL1

Outgoing (14)

TargetRelationTypeStr
h-cc077b4f0dtargeted_byhypothesis1.00
h-811520b92ftargeted_byhypothesis1.00
h-21d655104etargeted_byhypothesis1.00
h-1dd95a85f3targeted_byhypothesis1.00
h-37fc3b23a5targeted_byhypothesis1.00

Incoming (16)

SourceRelationTypeStr
h-1dd95a85f3targetshypothesis1.00
h-37fc3b23a5targetshypothesis1.00
h-803b338102targetshypothesis1.00
h-9d07f0457atargetshypothesis1.00
h-cc077b4f0dtargetshypothesis1.00

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
AAV-PHP.eB-Mediated Microglial IGFBPL1 Expression 0.720 drug delivery Can IGFBPL1 therapeutics effectively cro
Focused Ultrasound with Microbubble Contrast Agents 0.660 drug delivery Can IGFBPL1 therapeutics effectively cro
IGFBPL1-Mediated Homeostatic Restoration 0.584 Alzheimer's disease Neuroinflammation and microglial priming
IGFBPL1-Mediated Microglial Reprogramming 0.579 neurodegeneration Neuroinflammation and microglial priming
Fusing IGFBPL1 to IGF-1 for Receptor-Mediated BBB Transcytos 0.550 drug delivery Can IGFBPL1 therapeutics effectively cro
Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA 0.520 drug delivery Can IGFBPL1 therapeutics effectively cro
Intranasal IGFBPL1 Delivery via Olfactory Pathway 0.470 drug delivery Can IGFBPL1 therapeutics effectively cro
Monocyte Trojan Horse Cell Therapy 0.450 drug delivery Can IGFBPL1 therapeutics effectively cro
IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability 0.420 drug delivery Can IGFBPL1 therapeutics effectively cro

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can IGFBPL1 therapeutics effectively cross the blood-brain barrier to reach CNS

drug delivery | 2026-04-06 | 7 hypotheses Top: 0.720

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651

Experiments (1)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
bEV-mediated synaptic pruning via C1q-C3 pathway exploratory Alzheimer's disease 0.850 0.00 microglia and synapses (in viv proposed N/A

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Insulin-Like Growth Factor Signaling in Alzheimer's Disease: Pathophysiology and [PMID:39240280] Miao J, Zhang Y, Su C, Zheng Q, Guo J Molecular neurobiology 2025 1
IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury b [PMID:40294852] Li Y, Jiang J, Zhuo Y, Li J, Li Y, Xia Y Biochimica et biophysica acta. 2025 1
Functional assessments through novel proteomics approaches: Application to insul [PMID:30412730] Ayyadevara S, Ganne A, Hendrix RD, Balas Journal of neuroscience method 2019 1
Neuronal functions of FOXO/DAF-16. [PMID:28447066] Kim SY, Webb AE Nutrition and healthy aging 2017 1
Caloric restriction. [PMID:21840335] Speakman JR, Mitchell SE Molecular aspects of medicine 2011 1
Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pi [PMID:22039242] Arroba AI, Alvarez-Lindo N, van Rooijen Investigative ophthalmology & 2011 1
Semaglutide treatment reverses HFD induced hippocampal microglia activation and [PMID:41916100] ["Gong Haodong", "Liu Junlu", "Wang Yiha Tissue & cell 2026 0
α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Ca [PMID:38378800] ["Leandrou Emmanouela", "Chalatsa Ioanna Translational neurodegeneratio 2024 0
IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinfla [PMID:37527036] Pan L, Cho KS, Wei X, Xu F, Lennikov A, Cell reports 2023 0

Debates (3)

Multi-agent debates referencing this entity

The debate highlighted IGFBPL1's potential as a microglial master regulator but

closed · Rounds: 4 · Score: 0.69 · 2026-04-22

Investigate mechanistic links between early microglial priming states, neuroinfl

closed · Rounds: 4 · Score: 0.86 · 2026-04-12

Investigate mechanistic links between early microglial priming states, neuroinfl

closed · Rounds: 5 · Score: 0.95 · 2026-04-12