Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CLOCK, ARNTL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | associated_with | disease | 0.50 |
| IL1B, TNFA, NLRP3 | co_associated_with | gene | 0.40 |
| IGFBPL1 | co_associated_with | gene | 0.40 |
| DNMT3A, HDAC1/2 | co_associated_with | gene | 0.40 |
| GPR43, GPR109A | co_associated_with | gene | 0.40 |
| HIF1A, NFKB1 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C1QA, C3, CX3CR1, CX3CL1 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Temporal Gating of Microglial Responses | 0.565 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Transcriptomic profiling and differential expression analysis | exploratory | Alzheimer's disease | 0.900 | 0.00 | 1-month-old APP/PS1 mice cereb | proposed | N/A |
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
| qPCR and western blot analysis of microvascular functional molecules | exploratory | Alzheimer's disease | 0.850 | 0.00 | 1-month-old APP/PS1 mice cereb | proposed | N/A |
| Cell-cell interaction analysis of perivascular-microglial crosstalk | exploratory | Alzheimer's disease | 0.800 | 0.00 | AD mouse models | proposed | N/A |
| Morphological characterization of microglial states in human brain | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The mPFC molecular clock mediates the effects of sleep deprivation on depression [PMID:41023421] | Gardner W, Sarrazin DH, Balzinger M, Mar | Mol Psychiatry | 2026 | 0 |
| Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646] | Lin L, Liang X, Xu Z, Li Y, Guo Z et al. | Biomaterials | 2026 | 0 |
| Influence of sleep duration on cumulative genetic effects on obesity and related [PMID:41205781] | Zhang M, Lin J, Liu S, Jiang Y, Meng M e | Gene | 2026 | 0 |
| Clock gene influences on sleep quality and HPA axis in major depressive disorder [PMID:41429085] | Ferrer A, Pelegrí A, Labad J, Sagués T, | Sleep Med | 2026 | 0 |
| Light-at-night exposure drives myopia via melanopsin signalling. [PMID:41772203] | Li J, Li C, Wang M, Meng J, Dang J et al | Sci China Life Sci | 2026 | 0 |
| Circadian reprogramming by timed sodium intake reveals transcriptional pathways [PMID:41824567] | Torimitsu T, Kinouchi K, Changizi Ashtia | Sci Adv | 2026 | 0 |
| Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat [PMID:41925987] | Al Saeedy DY, Hawkins E, Dozmorov MG, Tr | J Mol Neurosci | 2026 | 0 |
| A role for the cholinergic neuron circadian clock in RNA metabolism and mediatin [PMID:41397872] | Tam SB, Waldeck NJ, Wright M, Mojsilovic | Life science alliance | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.86 · 2026-04-12
closed · Rounds: 5 · Score: 0.95 · 2026-04-12
Hypotheses and analyses mentioning CLOCK, ARNTL in their description or question text
No additional research found