Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Glucosylceramide: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Gaucher disease | contributes_to | disease | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GBA | modulates | gene | 0.70 |
| glucocerebrosidase | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Glucosylceramide Accumulation from GCase Deficiency Disrupts | 0.700 | neurodegeneration | - |
| Glucosylceramide accumulation nucleates alpha-synuclein aggr | 0.525 | Parkinson's disease | GBA-Synuclein Loop Therapeutics for PD |
| Glucosylceramide-mediated feedback loop drives GBA-synuclein | 0.380 | Parkinson's disease | GBA-Synuclein Loop: Therapeutic Strategi |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Pain has been frequently reported as an initial symptom and the most t | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Glucosylceramide in their description or question text
No additional research found