Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRIP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GRIP2 |
| Full Name | Glutamate Receptor Interacting Protein 2 |
| Aliases | Page for GRIP2, Page for GRIP2 Protein |
| Chromosome | 3p24.3 |
| Protein Type | Protein |
| Function | is a neuronal scaffolding protein that plays essential roles in synaptic function, plasticity, and trafficking of ionotropic glutamate receptors. |
| Primary Expression | the brain, with high levels in the hippocampus, cortex, and cerebellum—regions critical for learning, memory, and motor coord |
| Molecular Weight | 112.8 kDa |
| Amino Acids | 1112 aa |
| UniProt ID | Search UniProt |
| GeneCards | GRIP2 |
| Human Protein Atlas | GRIP2 |
| PDZ domains 1-2 | Bind to the C-terminal PDZ-binding motifs of AMPA receptor subunits |
| PDZ domains 3-5 | Interact with other scaffolding proteins (GRIP1, PICK1) |
| PDZ domains 6-7 | Connect to additional binding partners and signaling proteins |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GRIP2["GRIP2"]
neurodegeneration["neurodegeneration"]
GRIP2 -->|"implicated_in"| neurodegeneration
style GRIP2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GRIP2 in their description or question text
No additional research found