| Gene Symbol | GRIP2 |
| Full Name | Glutamate Receptor Interacting Protein 2 |
| Aliases | Page for GRIP2, Page for GRIP2 Protein |
| Chromosome | 3p24.3 |
| Protein Type | Protein |
| Function | is a neuronal scaffolding protein that plays essential roles in synaptic function, plasticity, and trafficking of ionotropic glutamate receptors. |
| Primary Expression | the brain, with high levels in the hippocampus, cortex, and cerebellum—regions critical for learning, memory, and motor coord |
| Molecular Weight | 112.8 kDa |
| Amino Acids | 1112 aa |
| UniProt ID | Search UniProt |
| GeneCards | GRIP2 |
| Human Protein Atlas | GRIP2 |
| Synaptic dysfunction | Aβ oligomers disrupt AMPA receptor trafficking, potentially involving GRIP2-mediated pathways |
| [Tau](/proteins/tau) pathology | Hyperphosphorylated tau affects synaptic scaffolding proteins |
| Neuroinflammation | Inflammatory cytokines alter GRIP2 expression and function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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