protein

GM-CSF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GM-CSF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

5Outgoing

6Incoming

0Experiments

0Debates

Summary

Page for GM-CSF Receptor Common Beta Chain

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🔬 Protein Info

Gene Symbol	GM
Chromosome	22q12.1
Function	Granulocyte-macrophage colony-stimulating factor receptor common beta chain (CSF2RB) is the shared signaling component of the GM-CSF receptor family.
GeneCards	GM
Human Protein Atlas	GM
Interactions	CCL2
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    N0["GM-CSF"]
    N1["Lactosylceramide"]
    N1 -->|"regulates"| N0
    N2["LacCer"]
    N2 -->|"upregulates"| N0
    N3["Monocyte Activation"]
    N0 -->|"mediates"| N3
    N1 -->|"upregulates"| N0
    N4["Astrocytes"]
    N0 -->|"activates"| N4
    N5["Astrocyte"]
    N0 -->|"activates"| N5
    N6["Macrophage"]
    N0 -->|"activates"| N6
    N7["MONOCYTES"]
    N0 -->|"activates"| N7
    N8["microglia"]
    N8 -->|"activates"| N0
    N9["CCL2"]
    N9 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N9 protein

Outgoing (5)

Target	Relation	Type	Str
Monocyte Activation	mediates	process	0.85
Astrocytes	activates	cell_type	0.50
Astrocyte	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
MONOCYTES	activates	concept	0.50

Incoming (6)

Source	Relation	Type	Str
Lactosylceramide	regulates	compound	0.90
LacCer	upregulates	compound	0.90
Lactosylceramide	upregulates	compound	0.85
LACCER	regulates	compound	0.80
microglia	activates	cell_type	0.50
CCL2	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GM-CSF in their description or question text

No additional research found