cell 615 words KG: ent-gene-9f063e98
Contents

iPSC-Derived LRRK2 G2019S Dopaminergic Neurons

🔬 Protein Info
Gene Symbolent-gene-9f063e98
LRRK2 proteinLeucine-rich repeat kinase 2, the target gene
Dopaminergic neuronsThe primary vulnerable cell type
Parkinson's diseaseThe associated neurodegenerative condition
Rab GTPasesDownstream
KG Connections22 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

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Related Hypotheses (9)

Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
...
Score: 0.68
Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61

Related Analyses (11)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · completed · Score: 0.40

Knowledge Graph (12 edges)

40690364 counteracts ent-gene-9f063e98
40690364 phosphorylates ent-gene-9f063e98
38307024 phosphorylates and inactivates ent-gene-9f063e98
33177079 is recruited to ent-gene-9f063e98
33177079 recruits ent-gene-9f063e98
33177079 recruits JIP4 to lysosomes via phosphorylation of ent-gene-9f063e98
33177079 is orchestrated by ent-gene-9f063e98
32853409 phosphorylates ent-gene-9f063e98
34125248 is an endogenous substrate of ent-gene-9f063e98
38307024 phosphorylates ent-gene-9f063e98

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