Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FUS-: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ASO-Mediated Exon Skipping to Restore FUS-TAZ Chaperone Axis | 0.720 | neurodegeneration | How does FUS loss-of-function in TAZ reg |
| Optogenetic viral vector delivery via tFUS-mediated blood-br | 0.622 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Cell-state stratification is required to resolve Cell-Autono | 0.612 | neurodegeneration | Cell-Autonomous vs Non-Cell-Autonomous M |
| FUS-ALS-Specific Ferroptosis Vulnerability Through NCOA4-Med | 0.480 | - | Ferroptosis in ALS and motor neuron dise |
| FUS-Enhanced AAV-PHP.eB Delivery for Microglial IGFBPL1 Expr | 0.380 | drug delivery | Can IGFBPL1 therapeutics effectively cro |
| FUS-Enhanced AAV-PHP.eB Delivery of IGFBPL1 to Microglia | 0.338 | drug delivery | Can IGFBPL1 therapeutics effectively cro |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| S-equol-induced ferroptosis mechanism in TNBC cells | exploratory | Triple negative breast cancer | 0.900 | 0.00 | TNBC cell lines | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Focused ultrasound-mediated APOE4 knockdown in mouse brain. [PMID:40665471] | Zheng K, Tsitsos FN, Batts AJ, Ji R, Nur | Alzheimer's & dementia : the j | 2025 | 0 |
| Focused ultrasound widely broadens AAV-delivered Cas9 distribution and activity. [PMID:39893321] | Gumusgoz E, Kasiri S, Youssef I, Verma M | Gene therapy | 2025 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinfla [PMID:37527036] | Pan L, Cho KS, Wei X, Xu F, Lennikov A, | Cell reports | 2023 | 0 |
| Incisionless targeted adeno-associated viral vector delivery to the brain by foc [PMID:36152518] | Unknown | EBioMedicine | 2022 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning FUS- in their description or question text