gene

FBXO3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FBXO3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

10Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for FBXO3 — F-Box Only Protein 3

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🧬 Gene Info

Gene Symbol	FBXO3
Full Name	F-Box Only Protein 3
Chromosome	19p13.3
Protein Family	F-box protein family, FBXO subfamily
Protein Type	Ligase
Function	FBXO3 is a substrate recognition component of SCF ubiquitin ligase complexes:
Molecular Weight	52 kDa
Amino Acids	449 aa
Pathways	NF-κB, NF-κB Signaling
UniProt ID	Q9UK96
NCBI Gene ID	115932
Ensembl ID	ENSG00000109220
GeneCards	FBXO3
Human Protein Atlas	FBXO3
Associated Diseases	Acute Lung Allograft Rejection, Cerebral Ischemia/Reperfusion Injury, Chronic Lung Allograft Dysfunction
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FBXO3 — AlphaFold Q9UK96 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FBXO3["FBXO3"]
    Neuroinflammation["Neuroinflammation"]
    FBXO3 -->|"associated_with"| Neuroinflammation
    Cerebral_Ischemia_Reperfusion_Injury{"Cerebral Ischemia/Reperfusion Injury"}
    FBXO3 -->|"associated_with"| Cerebral_Ischemia_Reperfusion_Injury
    Neuronal_Damage["Neuronal Damage"]
    FBXO3 -->|"inhibits"| Neuronal_Damage
    SCF_E3_Ubiquitin_Ligase_Complex["SCF E3 Ubiquitin Ligase Complex"]
    FBXO3 -->|"binds"| SCF_E3_Ubiquitin_Ligase_Complex
    p53("p53")
    FBXO3 -->|"binds"| p53
    p53_Activity["p53 Activity"]
    FBXO3 -->|"regulates"| p53_Activity
    FBXL2["FBXL2"]
    FBXO3 -->|"associated_with"| FBXL2
    Acute_Lung_Allograft_Rejection{"Acute Lung Allograft Rejection"}
    FBXO3 -->|"associated_with"| Acute_Lung_Allograft_Rejection
    Chronic_Lung_Allograft_Dysfunction{"Chronic Lung Allograft Dysfunction"}
    FBXO3 -->|"associated_with"| Chronic_Lung_Allograft_Dysfunction
    Cytokine_Secretion["Cytokine Secretion"]
    FBXO3 -->|"associated_with"| Cytokine_Secretion
    Lysophagy["Lysophagy"]
    FBXO3 -->|"activates"| Lysophagy
    neurodegeneration["neurodegeneration"]
    FBXO3 -->|"implicated_in"| neurodegeneration

Outgoing (10)

Target	Relation	Type	Str
Cerebral Ischemia/Reperfusion Injury	associated_with	disease	0.80
Neuronal Damage	inhibits	phenotype	0.80
SCF E3 Ubiquitin Ligase Complex	binds	entity	0.80
p53	binds	protein	0.80
p53 Activity	regulates	biological_process	0.80
FBXL2	associated_with	gene	0.80
Acute Lung Allograft Rejection	associated_with	disease	0.80
Chronic Lung Allograft Dysfunction	associated_with	disease	0.80
Cytokine Secretion	associated_with	biological_process	0.80
Lysophagy	activates	biological_process	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FBXO3 in their description or question text

No additional research found