| Gene Symbol | F-box Protein 31 |
| Chromosome | 16q24.2 |
| Protein Family | F-box family, SCF ubiquitin ligase complex |
| Function | encodes a substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex, a critical component of the ubiquitin-proteasome system (UPS). |
| Subcellular Localization | </strong></td><td>Nucleus, Cytoplasm</td></tr> |
| Amino Acids | 483 aa |
| UniProt ID | Q8IFY6 |
| NCBI Gene ID | 79791 |
| Ensembl ID | ENSG00000103265 |
| OMIM | 609102 |
| F-box motif | N-terminal domain (approximately 50 amino acids) that mediates binding to Skp1 and Cul1 |
| C-terminal substrate recognition domain | Variable region responsible for binding specific substrates |
| Nuclear localization signal (NLS) | Present in some isoforms, enabling nuclear-cytoplasmic shuttling |
| Multiple phosphorylation sites | Regulate substrate recognition and protein stability |
| G1/S checkpoint | Targets cyclin D1 for ubiquitination, preventing inappropriate cell cycle re-entry in neurons |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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