Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Dha: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | protects_against | process | 0.90 |
| Npd1 | product_of | compound | 0.85 |
| BACE1 | downregulates | protein | 0.85 |
| Kennedy Cycle | involved_in | pathway | 0.85 |
| Alzheimer'S Disease | protects_against | disease | 0.80 |
| Major Depression | treats | disease | 0.80 |
| Neuroprotection | mediates | process | 0.80 |
| BACE1 | inhibits | protein | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ω-3 Docosahexaenoic Acid (DHA) Epoxide Generation via CYP2J2 | 0.752 | lipidomics | Lipid metabolism dysregulation in Alzhei |
| LXRβ-Selective Agonism Enhances CYP2J2-Mediated DHA Epoxide | 0.380 | lipidomics | Lipid metabolism dysregulation in Alzhei |
| ω-3 Docosahexaenoic Acid (DHA) Metabolism via 15-Lipoxygenas | 0.380 | lipidomics | Lipid metabolism dysregulation in Alzhei |
| CYP2J2-Derived DHA Epoxides Modulate Microglial M2 Polarizat | 0.380 | lipidomics | Lipid metabolism dysregulation in Alzhei |
| CYP2J2-Generated DHA Epoxides Enhance LXRβ-Mediated APOE Lip | 0.380 | lipidomics | Lipid metabolism dysregulation in Alzhei |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition. [PMID:34422879] | ["Milo\u0161evi\u0107 M", "Arsi\u0107 A" | Frontiers in nutrition | 2021 | 0 |
| Dietary DHA and health: cognitive function ageing. [PMID:27866493] | Unknown | Nutr Res Rev | 2016 | 0 |
| Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice. [PMID:20211757] | Unknown | Biochim Biophys Acta | 2010 | 0 |
| Survival signalling in Alzheimer's disease. [PMID:17073801] | Unknown | Biochem Soc Trans | 2006 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Dha in their description or question text
No additional research found