Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNMT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| gene promoter methylation | regulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 5-azacytidine | inhibits | drug | 0.90 |
| decitabine | inhibits | drug | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| DNMT1-Targeting Antisense Oligonucleotide Reset | 0.648 | neurodegeneration | Epigenetic clocks and biological aging i |
| DNMT1 Compensation Window During Synaptic Resilience Phase | 0.528 | neurodegeneration | What is the optimal therapeutic window d |
| DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Sca | 0.460 | neurodegeneration | Investigate mechanisms of epigenetic rep |
| DNMT1 Downregulation to Correct Genome-Wide Hypomethylation | 0.380 | neurodegeneration | Comparative epigenetic signatures across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.387
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.643
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Assessment of Out-of-Pocket Costs for Robotic Cancer Surgery in US Adults. [PMID:31940036] | Nabi J, Friedlander DF, Chen X, Cole AP, | JAMA Netw Open | 2020 | 1 |
| Multidisciplinary Approach to Interstitial Lung Diseases: Nothing Is Better than [PMID:32709146] | Vancheri C, Basile A | Diagnostics (Basel) | 2020 | 1 |
| Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus. [PMID:29887377] | Quinodoz SA, Ollikainen N, Tabak B, Pall | Cell | 2018 | 1 |
| Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. [PMID:28319113] | Shen JP, Zhao D, Sasik R, Luebeck J, Bir | Nat Methods | 2017 | 1 |
| The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation [PMID:20644199] | McKenna A, Hanna M, Banks E, Sivachenko | Genome Res | 2010 | 1 |
| Prevalence of clinical and radiographic signs of osteoarthrosis of the temporoma [PMID:20395464] | Schmitter M, Essig M, Seneadza V, Balke | Dentomaxillofac Radiol | 2010 | 1 |
| Disrupting the epigenetic alliance: structural insights and therapeutic strategi [PMID:40960568] | Kamel EM, Ali MAM, Allam AA, Ahmed NA, A | Functional & integrative genom | 2025 | 0 |
| Flow cytometry of DNMT1 as a biomarker of hypomethylating therapies. [PMID:38345160] | Woost PG, William BM, Cooper BW, Ueda Os | Cytometry. Part B, Clinical cy | 2024 | 0 |
| DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppres [PMID:38755637] | Liu Y, Sun Y, Yang J, Wu D, Yu S, Liu J, | Molecular cancer | 2024 | 0 |
| Bi-functional CpG-STAT3 decoy oligonucleotide triggers multilineage differentiat [PMID:39171140] | Wang D, Kaniowski D, Jacek K, Su YL, Yu | Molecular therapy. Nucleic aci | 2024 | 0 |
| A precise and efficient circular RNA synthesis system based on a ribozyme derive [PMID:37378451] | Cui J, Zhang L, Zhang Z, Luo X, Liu Y, L | Nucleic acids research | 2023 | 0 |
| Channel branching and zigzagging in negative cloud-to-ground lightning. [PMID:28615706] | ["Jiang R", "Qie X", "Zhang H", "Liu M", | Scientific reports | 2017 | 0 |
| Sequential transcriptional waves direct the differentiation of newborn neurons i [PMID:26940868] | ["Telley L", "Govindan S", "Prados J", " | Science (New York, N.Y.) | 2016 | 0 |
| Incorporating theology into medical education. [PMID:23209119] | Adam Miller | CMAJ : Canadian Medical Associ | 2013 | 0 |
Multi-agent debates referencing this entity
completed · Rounds: 5 · Score: 0.50 · 2026-04-25
closed · Rounds: 4 · Score: 0.68 · 2026-04-21
Hypotheses and analyses mentioning DNMT in their description or question text
No additional research found