gene

dab2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about dab2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

1Outgoing

2Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	DAB2
Full Name	Disabled Clathrin Adaptor Protein
Chromosome	5p13.2
Protein Type	Adaptor Protein
Function	encodes a clathrin-associated adaptor protein that plays critical roles in endocytosis, signal transduction, and protein homeostasis.
Amino Acids	830 aa
Exons	22
Pathways	Notch
UniProt ID	[P98073](https://www.uniprot.org/uniprot/P98073)
Ensembl ID	ENSG00000153046
GeneCards	DAB2
Human Protein Atlas	DAB2
DAB2 isoform A (p96)	Full-length protein (830 aa)
DAB2 isoform B (p67)	Truncated isoform lacking N-terminal sequences
LDL Receptor Family	LDLR, LRP1, LRP2
Associated Diseases	Alzheimer's Disease, Parkinson's Disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DAB2 — Disabled Clathrin Adaptor Protein

gene · 1339 words

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Pathway Diagram

flowchart TD
    DAB2["DAB2"] -->|"implicated in"| neurodegeneration["neurodegeneration"]
    AGGF1["AGGF1"] -->|"upregulates"| DAB2["DAB2"]
    Neurodegeneration["Neurodegeneration"] -->|"regulates"| Apoptosis["Apoptosis"]
    Neurodegeneration["Neurodegeneration"] -->|"activates"| Mtor["Mtor"]
    Neurodegeneration["Neurodegeneration"] -->|"activates"| Autophagy["Autophagy"]
    Neurodegeneration["Neurodegeneration"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    AGGF1["AGGF1"] -->|"activates"| VEGFA["VEGFA"]
    AGGF1["AGGF1"] -->|"upregulates"| FLT4["FLT4"]
    AGGF1["AGGF1"] -->|"upregulates"| EPHB4["EPHB4"]
    style DAB2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style neurodegeneration fill:#006494,stroke:#333,color:#e0e0e0
    style AGGF1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Apoptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Mtor fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Blood_Brain_Barrier fill:#1b5e20,stroke:#333,color:#e0e0e0
    style VEGFA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style FLT4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style EPHB4 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:DAB2	data_in	dataset_row	0.00

Incoming (2)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:DAB2	data_in	dataset_row	0.00
AGGF1	upregulates	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning dab2 in their description or question text

No additional research found