| Gene Symbol | CTNSPROTEIN |
| Protein Type | Transporter |
| Function | is a lysosomal membrane transporter protein critical for cystine efflux from lysosomes. |
| Subcellular Localization | to the lysosomal membrane, where it functions as an H⁺-driven cystine transporte |
| Molecular Weight | 42 kDa |
| GeneCards | CTNSPROTEIN |
| Human Protein Atlas | CTNSPROTEIN |
| N-terminal domain | Located in the lysosomal lumen, contains 7 N-glycosylation sites |
| Seven transmembrane helices (TM1-TM7) | Span the lysosomal membrane to form the cystine translocation pathway |
| Two PQ-loop motifs | Conserved Pro-Gln sequences in TM2 and TM5 essential for transport |
| C-terminal tail | Cytoplasmic, contains the GYDQL lysosomal sorting motif |
| Intralysosomal loops | Large glycosylated loops between TMs protect against lysosomal proteases |
| Autophagic flux | Reduced autophagosome-lysosome fusion |
| Chaperone-mediated autophagy | Impaired LAMP2A-dependent CMA |
| Endosomal trafficking | Delayed endosomal maturation and cargo sorting |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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