entity

CROSS_SEEDING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CROSS_SEEDING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

8Hypotheses

1Analyses

2Outgoing

7Incoming

11Experiments

1Debates

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Outgoing (2)

Target	Relation	Type	Str
multiple_system_atrophy	associated_with	disease	0.60
neurodegeneration	causes	disease	0.60

Incoming (7)

Source	Relation	Type	Str
HSPG2	platform_for	gene	0.75
prohibitin-2	associated_with	protein	0.60
beta_sheet_structure	promotes	pathway	0.60
protein_misfolding	causes	biological_process	0.60
transglutaminase-2	promotes	protein	0.60
glycosaminoglycan	promotes	pathway	0.60
microglia	inhibits	cell_type	0.60

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cross-Seeding Prevention Strategy	0.689	neurodegeneration	RNA binding protein dysregulation across
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro	0.642	neurodegeneration	What are the mechanisms by which gut mic
Tau Cross-Seeding and Interaction	0.610	neurodegeneration	What mechanisms underlie TDP-43's contri
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor	0.544	neurodegeneration	Protein aggregation cross-seeding across
Cross-Seeding: Gut Microbiome-Derived Bacterial Curli and Fu	0.540	neurodegeneration	How does gut microbiome dysbiosis contri

G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-	0.490	neurodegeneration	How do disease-associated mutations in G
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption	0.469	neurodegeneration	Protein aggregation cross-seeding across
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding	0.465	neurodegeneration	Protein aggregation cross-seeding across

Mentioning Analyses (1)

Scientific analyses that reference this entity

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.639

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Nation-wide NGS-based genetic screening of LGMD patients in US	exploratory	Limb-girdle muscular dystrophy	0.950	0.00	Human patients	proposed	N/A
TDP-43 mutant mouse model cGAS/STING pathway analysis	validation	amyotrophic lateral sclerosis	0.900	0.00	TDP-43 mutant mice	proposed	N/A
TDP-43 mitochondrial invasion and DNA release via mPTP	exploratory	amyotrophic lateral sclerosis	0.900	0.00	cultured cells	proposed	N/A
TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons	exploratory	Amyotrophic Lateral Sclerosis	0.900	0.00	iPSC-derived motor neurons	proposed	N/A
cGAS/STING pathway validation in TDP-43 mutant mice	validation	Amyotrophic Lateral Sclerosis	0.850	0.00	TDP-43 mutant mice	proposed	N/A
cGAMP biomarker analysis in ALS patient spinal cord samples	exploratory	Amyotrophic Lateral Sclerosis	0.800	0.00	Human ALS patient spinal cord	proposed	N/A
TDP-43 pathology prevalence and distribution in AD cases	exploratory	Alzheimer's disease	0.800	0.00	human postmortem brain tissue	proposed	N/A
Cognitive impact of TDP-43 pathology in AD patients	clinical	Alzheimer's disease	0.700	0.00	human patients	completed	N/A
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000
Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for P	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382]	Meneses A, Koga S, O'Leary J, Dickson DW	Mol Neurodegener	2021	2
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
Protein transmission in neurodegenerative disease. [PMID:32203399]	Peng C, Trojanowski JQ, Lee VM	Nat Rev Neurol	2020	2
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
N protein of PEDV plays chess game with host proteins by selective autophagy. [PMID:36861818]	Zhai X, Kong N, Zhang Y, Song Y, Qin W,	Autophagy	2023	1
ALS-related proteinopathies: From TDP-43 to mitochondrial proteinopathies. [PMID:41570741]	Genin EC, Paquis-Flucklinger V	Current opinion in neurobiolog	2026	0
Role of Alpha-Synuclein in Frontotemporal Dementia: Narrative Review. [PMID:41827903]	Bougea A	Cells	2026	0
Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2-Medi [PMID:41572443]	Xu Y, Sun Y, Zhou X, Song K, Yin C et al	Adv Sci (Weinh)	2026	0
Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiol [PMID:41666677]	Shao Z, Yang X, Wang B, Wang X, Zhao D e	Redox Biol	2026	0
Refolding-assisted purification of native full-length TDP-43 compatible with BSL [PMID:41692368]	Dehury S, Tiwari S, Los Rios P	Methods	2026	0
Small heat shock proteins HspB1 and HspB5 differentially alter the condensation [PMID:41854301]	Walker TB, Trowbridge JW, McMahon S, Mar	Protein Sci	2026	0
Structural and Mechanistic Heterogeneity of the Phase Separation and Aggregation [PMID:41871974]	Doke AA, Kirmire MS, Jha A, Jha SK	ACS Chem Neurosci	2026	0
Mitochondria-Related Pathogenic Genes in Paediatric Asthma: A Multi-Omics Mendel [PMID:41896191]	Zhang B, Li Y, Ding B, Li X, Lu Y	J Cell Mol Med	2026	0
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026	0
The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study [PMID:41883703]	Nassan M, Ayala I, Sloan J, Bonfitto A,	Neurology. Genetics	2026	0
Computational examination of magainin-I-KL mediated disruption of E. coli biofil [PMID:41724836]	Vinutha AS, Akshay S, Sree Agash SG, Cha	Archives of microbiology	2026	0
Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progressi [PMID:41540015]	Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du	International journal of oral	2026	0
The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E [PMID:41581877]	Gurnani B, Jain N	The Journal of biological chem	2026	0
DNAJB6: A guardian against neurodegeneration. [PMID:40536953]	Hentze J, Gelman A, Brudek T, Hansen C	Neural regeneration research	2026	0

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying protein aggregation cross-seeding across neur

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning CROSS_SEEDING in their description or question text

G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-Spreads Across Neura

Score: 0.490 · neurodegeneration · 2026-04-22

## Mechanistic Overview G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-Spreads Across Neural Circuits start

Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption

Score: 0.469 · neurodegeneration · 2026-04-02

Prohibitin-2 serves as a convergent mitochondrial platform where tau, α-synuclein, and TDP-43 interact and undergo confo

RNA-Binding Competition Therapy for TDP-43 Cross-Seeding

Score: 0.465 · neurodegeneration · 2026-04-02

Synthetic RNA aptamers designed to competitively bind TDP-43's RNA recognition motifs could prevent its interaction with