Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about transglutaminase-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| tau | cross-links | protein | 0.60 |
| alpha-synuclein | cross-links | protein | 0.60 |
| TDP-43 | cross-links | protein | 0.60 |
| protein_aggregation | promotes | biological_process | 0.60 |
| cross_seeding | promotes | biological_process | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TGM2 | encodes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Transglutaminase-2 Cross-Linking Inhibition Strategy | 0.639 | neurodegeneration | Protein aggregation cross-seeding across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.639
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TGM2 and implications for human disease: role of alternative splicing. [PMID:23276939] | Lai TS, Greenberg CS | Front Biosci (Landmark Ed) | 2013 | 1 |
| Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial [PMID:40619121] | Zhou G, Zhang M, Zheng S, Yang G, Li L e | J Adv Res | 2026 | 0 |
| The Search for a Universal Treatment for Defined and Mixed Pathology Neurodegene [PMID:39769187] | O'Day DH | International journal of molec | 2024 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegenerati [PMID:36421678] | ["O'Day D"] | Current issues in molecular bi | 2022 | 0 |
| Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulati [PMID:32704090] | Lee HJ, Jung YH, Choi GE | Cell Death Differ | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |
| Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies. [PMID:32751379] | Mohan M, Okeoma CM, Sestak K | International journal of molec | 2020 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning transglutaminase-2 in their description or question text
No additional research found