Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about prohibitin-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| mitochondria | localizes_to | cell_type | 0.60 |
| cross_seeding | associated_with | process | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PHB2 | encodes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption | 0.469 | neurodegeneration | Protein aggregation cross-seeding across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.639
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] | Yao RQ, Ren C, Xia ZF, Yao YM | Autophagy | 2021 | 2 |
| Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2-Medi [PMID:41572443] | Xu Y, Sun Y, Zhou X, Song K, Yin C et al | Adv Sci (Weinh) | 2026 | 0 |
| Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiol [PMID:41666677] | Shao Z, Yang X, Wang B, Wang X, Zhao D e | Redox Biol | 2026 | 0 |
| Mitochondria-Related Pathogenic Genes in Paediatric Asthma: A Multi-Omics Mendel [PMID:41896191] | Zhang B, Li Y, Ding B, Li X, Lu Y | J Cell Mol Med | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| Efficient PHB2 (prohibitin 2) exposure during mitophagy depends on VDAC1 (voltag [PMID:39513197] | ["Roy M", "Nandy S", "Marchesan E", "Ban | Autophagy | 2025 | 0 |
| Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related disea [PMID:39113560] | Di Rienzo M, Romagnoli A, Refolo G, Vesc | Autophagy | 2024 | 0 |
| Current opinions on mitophagy in fungi. [PMID:35793406] | Shen ZF, Li L, Zhu XM, Liu XH, Klionsky | Autophagy | 2023 | 0 |
| Harlequin syndrome associated with thoracic epidural anaesthesia. [PMID:35118419] | Persson RM, Tellnes K, Hoven H, Haaverst | Anaesthesia reports | 2022 | 0 |
| Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal o [PMID:34285270] | Fujiya Y, Harada T, Sugawara Y, Akeda Y, | Scientific reports | 2021 | 0 |
| The expression of PHB2 in the cochlea: Possible relation to age-related hearing [PMID:34435719] | ["Yu X", "Guan M", "Shang H", "Teng Y", | Cell biology international | 2021 | 0 |
| Massive Hemoptysis and Recurrent Infective Endocarditis in Intravenous Drug user [PMID:33154920] | Almutairi MD, El-Ghoneimy YA, Alghamdi A | Journal of the Saudi Heart Ass | 2020 | 0 |
| Evaluation of care coordination among healthy community-dwelling older adults fi [PMID:31296608] | Terri Kean | Evidence-based nursing | 2020 | 0 |
| High resolution spatiotemporal patterns of seawater temperatures across the Beli [PMID:33199700] | Helmuth B, Leichter JJ, Rotjan RD, Casti | Scientific data | 2020 | 0 |
| Prohibitin levels regulate OMA1 activity and turnover in neurons. [PMID:31819158] | ["Anderson C", "Kahl A", "Fruitman H", " | Cell death and differentiation | 2020 | 0 |
| Multiplexed orthogonal genome editing and transcriptional activation by Cas12a. [PMID:30559432] | Breinig M, Schweitzer AY, Herianto AM, R | Nature methods | 2019 | 0 |
| Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients [PMID:30078747] | Kahles A, Lehmann KV, Toussaint NC, Hüse | Cancer cell | 2018 | 0 |
| Macrophage migration inhibitory factor downregulation: a novel mechanism of resi [PMID:28218903] | Castro BA, Flanigan P, Jahangiri A, Hoff | Oncogene | 2017 | 0 |
| Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. [PMID:28017329] | ["Wei Y", "Chiang W", "Sumpter R", "Mish | Cell | 2017 | 0 |
| Remediation of textile effluents by membrane based treatment techniques: a state [PMID:25261752] | Dasgupta J, Sikder J, Chakraborty S, Cur | Journal of environmental manag | 2015 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning prohibitin-2 in their description or question text
No additional research found