gene

COX20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COX20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

COX20 (Cytochrome c Oxidase Assembly Factor 20) - essential mitochondrial protein for Complex IV assembly, associated with cerebellar ataxia and hearing loss

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🧬 Gene Info

Gene Symbol	COX20
Full Name	Cytochrome c Oxidase Assembly Factor COX20
Aliases	Cytochrome c Oxidase Assembly Factor 20, Cytochrome C Oxidase Assembly Factor
Chromosome	1p31.3
Function	is a nuclear-encoded mitochondrial protein that plays an indispensable role in the biogenesis of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain.
Primary Expression	High in cerebellum, inner ear, heart, skeletal muscle
Molecular Weight	22 kDa
Amino Acids	198 aa
UniProt ID	Q9Y4Y6
NCBI Gene ID	91574
Ensembl ID	ENSG00000173391
GeneCards	COX20
Human Protein Atlas	COX20
Transmembrane domain	Single α-helical transmembrane segment anchors COX20 in the inner mitochondrial membrane
Intermembrane space domain	C-terminal region faces the intermembrane space where it interacts with COX1 and other assembly factors
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: COX20 — AlphaFold Q9Y4Y6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

COX20 Gene - Cytochrome c Oxidase Assembly Factor

gene · 3906 words

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COX20 Protein (Cytochrome C Oxidase Assembly Factor)

protein · 841 words

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Pathway Diagram

graph TD
    COX20["COX20"]
    neurodegeneration["neurodegeneration"]
    COX20 -->|"implicated_in"| neurodegeneration
    style COX20 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning COX20 in their description or question text

No additional research found