protein

CHD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for CHD2 Protein

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🔬 Protein Info

Gene Symbol	CHD2
Protein Type	Gene
Function	CHD2 (Chromodomain Helicase DNA Binding Protein 2) is a member of the CHD (Chromodomain Helicase DNA-binding) family of ATP-dependent chromatin remodelers.
Primary Expression	the brain, particularly in: - Cerebral cortex - Hippocampus (CA1-CA3 regions) - [Cerebellum](/b
Molecular Weight	233 kDa
GeneCards	CHD2
Human Protein Atlas	CHD2
Neurodevelopment	Regulating genes critical for brain development, neuronal differentiation, and synapse formation
Epigenetic regulation	Depositing histone modifications and maintaining chromatin states
DNA damage response	Participating in repair of double-strand breaks
N-terminal tandem chromodomains	Recognize histone modifications (H3K4me3, H3K27me3)
Central SNF2 ATPase domain	Hydrolyzes ATP for chromatin remodeling
C-terminal DNA-binding domain	Binds DNA and nucleosomal DNA
Activity-dependent remodeling	Immediate-early gene activation
Synaptic plasticity	Reorganization of synaptic gene loci
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHD2["CHD2"]
    neurodegeneration["neurodegeneration"]
    CHD2 -->|"implicated_in"| neurodegeneration
    style CHD2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning CHD2 in their description or question text

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