| Gene Symbol | CHD2 |
| Aliases | CHD2PROTEIN |
| Protein Type | Gene |
| Function | CHD2 (Chromodomain Helicase DNA Binding Protein 2) is a member of the CHD (Chromodomain Helicase DNA-binding) family of ATP-dependent chromatin remodelers. |
| Primary Expression | the brain, particularly in: - Cerebral cortex - Hippocampus (CA1-CA3 regions) - [Cerebellum](/b |
| Subcellular Localization | ** | Nucleus | |
| Molecular Weight | 233 kDa |
| GeneCards | CHD2 |
| Human Protein Atlas | CHD2 |
| Double chromodomains | At the N-terminus, bind to methylated histone H3K4me3 and H3K9me3 |
| SNF2 helicase domain | Central ATP-dependent chromatin remodeling engine |
| DNA-binding domain | Facilitates interaction with nucleosomal DNA |
| C-terminal domains | Additional protein-protein interaction motifs |
| Nucleosome sliding | Repositions nucleosomes along DNA |
| Histone exchange | Facilitates histone variant incorporation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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