| Gene Symbol | CHD2 |
| Protein Type | Gene |
| Function | CHD2 (Chromodomain Helicase DNA Binding Protein 2) is a member of the CHD (Chromodomain Helicase DNA-binding) family of ATP-dependent chromatin remodelers. |
| Primary Expression | the brain, particularly in: - Cerebral cortex - Hippocampus (CA1-CA3 regions) - [Cerebellum](/b |
| Molecular Weight | 233 kDa |
| GeneCards | CHD2 |
| Human Protein Atlas | CHD2 |
| Neurodevelopment | Regulating genes critical for brain development, neuronal differentiation, and synapse formation |
| Epigenetic regulation | Depositing histone modifications and maintaining chromatin states |
| DNA damage response | Participating in repair of double-strand breaks |
| N-terminal tandem chromodomains | Recognize histone modifications (H3K4me3, H3K27me3) |
| Central SNF2 ATPase domain | Hydrolyzes ATP for chromatin remodeling |
| C-terminal DNA-binding domain | Binds DNA and nucleosomal DNA |
| Activity-dependent remodeling | Immediate-early gene activation |
| Synaptic plasticity | Reorganization of synaptic gene loci |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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