Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Cerebellar Degeneration-Related Protein 2 - role in paraneoplastic cerebellar degeneration and autoimmune neurological disorders
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| Gene Symbol | CDR2 |
| Aliases | Cerebellar Degeneration-Related Protein 2 |
| Chromosome | 12p13 |
| Protein Type | Gene |
| Function | is a cytoplasmic antigen that serves as the primary autoantibody target in paraneoplastic cerebellar degeneration (PCD), a rare autoimmune disorder affecting the cerebellum. |
| Primary Expression | neural tissue |
| Molecular Weight | 55 kDa |
| Amino Acids | 520 aa |
| GeneCards | CDR2 |
| Human Protein Atlas | CDR2 |
| Cerebellar cortex | Highest expression in Purkinje cell bodies and dendrites |
| Hippocampus | Moderate expression in pyramidal neuron layers |
| Cerebral cortex | Lower expression in layer 5 pyramidal neurons |
| Brainstem | Expression in specific nuclei including the inferior olive |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CDR2["CDR2"]
Azole_Resistance["Azole Resistance"]
CDR2 -->|"contributes_to"| Azole_Resistance
neurodegeneration["neurodegeneration"]
CDR2 -->|"implicated in"| neurodegeneration
style CDR2 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Azole Resistance | contributes_to | mechanism | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CDR1 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CDR2 in their description or question text
No additional research found