Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CDR1 |
| Full Name | Cerebellar Degeneration-Related Protein 1 (CDR1AS) |
| Chromosome | Xq27.1 |
| Function | is a stable circular RNA molecule that lacks the 5' cap and 3' polyadenylated tail typical of most coding transcripts. |
| UniProt ID | Q9UIU7 |
| Ensembl ID | ENSG00000283757 |
| GeneCards | CDR1 |
| Human Protein Atlas | CDR1 |
| BACE1 | The β-secretase enzyme that cleaves amyloid precursor protein (APP) to produce amyloid-beta peptides. Increased BACE1 activity promotes amyloid production, a hallmark of AD pathogenesis. |
| SNCA | α-Synuclein, the protein that forms Lewy bodies in PD. Proper regulation of SNCA expression is critical, as overexpression can lead to aggregation and toxicity. |
| UCHL1 | Ubiquitin carboxy-terminal hydrolase L1, an enzyme important for protein degradation. Loss of UCHL1 function contributes to protein aggregation. |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CDR1["CDR1"]
Azole_Resistance["Azole Resistance"]
CDR1 -->|"contributes_to"| Azole_Resistance
neurodegeneration["neurodegeneration"]
CDR1 -->|"implicated in"| neurodegeneration
style CDR1 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Azole Resistance | contributes_to | mechanism | 0.80 |
| CDR2 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CDR1 in their description or question text
No additional research found