Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BBB DISRUPTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | BBB DISRUPTION |
| Related Diseases | NEURODEGENERATION, SEPSIS, STROKE |
graph TD
BBB_DISRUPTION[BBB DISRUPTION]
BBB_DISRUPTION -.biomarker for.-> Neuronal_Damage[Neuronal Damage]
BBB_DISRUPTION -->|inhibits| MICROGLIA[MICROGLIA]
BBB_DISRUPTION -->|exacerbates| NEURODEGENERATION[NEURODEGENERATION]
Cellular_Biomarkers[Cellular Biomarkers] -.biomarker for.-> BBB_DISRUPTION
Molecular_Biomarkers[Molecular Biomarkers] -.biomarker for.-> BBB_DISRUPTION
Imaging_Biomarkers[Imaging Biomarkers] -.biomarker for.-> BBB_DISRUPTION
reactive_oxygen_species[reactive oxygen species] -->|activates| BBB_DISRUPTION
STROKE[STROKE] -->|activates| BBB_DISRUPTION
SEPSIS[SEPSIS] -->|activates| BBB_DISRUPTION| Target | Relation | Type | Str |
|---|---|---|---|
| Neuronal Damage | biomarker_for | phenotype | 0.85 |
| MICROGLIA | inhibits | cell_type | 0.70 |
| NEURODEGENERATION | exacerbates | phenotype | 0.70 |
| HYPOTHALAMUS | associated_with | brain_region | 0.50 |
| AMYLOID PET | associated_with | biomarker | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Bbb Permeability | associated_with | biomarker | 0.90 |
| Cellular Biomarkers | biomarker_for | biomarker | 0.85 |
| Molecular Biomarkers | biomarker_for | biomarker | 0.85 |
| Imaging Biomarkers | biomarker_for | biomarker | 0.85 |
| Neurodegeneration | associated_with | phenotype | 0.85 |
| STROKE | activates | disease | 0.70 |
| reactive oxygen species | activates | process | 0.70 |
| SEPSIS | activates | disease | 0.65 |
| AQP4 | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Piezoelectric Nanochannel BBB Disruption | 0.519 | neurodegeneration | Blood-brain barrier transport mechanisms |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Compare uptake with/without magnetic particles using tight junc | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $120,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $130,000 |
| Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Vascular Contribution to Alzheimer's Disease — Beyond Amyloid | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Dolutegravir induces endoplasmic reticulum stress at the blood-brain barrier. [PMID:39985305] | Huang C, Qu QR, Hoque MT, Bendayan R | FASEB J | 2025 | 1 |
| Profiling Tight Junction Protein Expression in Brain Vascular Malformations. [PMID:40429705] | Pedrosa L, Mosteiro A, Reyes L, Amaro S, | Int J Mol Sci | 2025 | 1 |
| Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation o [PMID:33280500] | Yang Z, Lin P, Chen B, Zhang X, Xiao W, | Autophagy | 2021 | 1 |
| ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818] | ["Li X", "Huang J", "Zhou Y", "Chen X", | International journal of pharm | 2026 | 0 |
| Claudins proteins in brain tumors: expression patterns and therapeutic target. [PMID:41399659] | ["Romanowicz A", "\u0141ukaszewicz-Zaj\u | Biochemia medica | 2026 | 0 |
| Testicular Gap (CX43) and Tight Junction (OCLN, CLDN3, 5 and 11) Components in t [PMID:41594443] | Goericke-Pesch S, Röhrs L, Wallrabenstei | Animals : an open access journ | 2026 | 0 |
| Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:40994007] | ["Cueva Vargas J", "Belforte N", "Vidal- | Molecular therapy : the journa | 2026 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Artemether Improves Aβ [PMID:40493345] | ["Cai J", "Liu Y", "Gong L", "Deng S", " | Molecular neurobiology | 2025 | 0 |
| Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:39975311] | ["Cueva-Vargas J", "Belforte N", "Vidal- | bioRxiv : the preprint server | 2025 | 0 |
| Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Imp [PMID:40244194] | ["Chen A", "Duan Y", "Zhou S", "Du F", " | International journal of molec | 2025 | 0 |
| Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional p [PMID:40018968] | Gowrikumar S, Tarudji A, McDonald BZ, Ba | Tissue barriers | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-b [PMID:36969875] | ["Huang C", "Hoque T", "Bendayan R"] | Frontiers in pharmacology | 2023 | 0 |
| Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated [PMID:28490769] | Du Y, Xu JT, Jin HN, Zhao R, Zhao D, Du | Scientific reports | 2017 | 0 |
| Anti-inflammatory activity of Barleria lupulina: Identification of active compou [PMID:27660013] | ["Senger D", "Hoang M", "Kim K", "Li C", | Journal of ethnopharmacology | 2016 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BBB DISRUPTION in their description or question text
No additional research found