Alzheimer's Disease
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114
hypotheses
55
debates
19
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.96
· therapeutic
0.95
· therapeutic
0.91
· therapeutic
0.90
· therapeutic
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stabilization
85% yes
💬 3
0.87
· therapeutic
0.87
· mechanistic
0.87
· therapeutic
0.86
· therapeutic
0.85
· therapeutic
Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance
82% yes
💬 2
0.85
· therapeutic
💬 Debates & Sessions
Browse →
💬
Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to restore hippocampal-cortical connectivity in early MCI
hypothesis_debate · 2026-04-28
· score 0.9
💬
Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD
hypothesis_debate · 2026-04-28
· score 0.9
💬
Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons to restore AnkyrinG-dependent AIS integrity and hippocampal g
hypothesis_debate · 2026-04-27
· score 0.7
💬
Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD
hypothesis_debate · 2026-04-27
· score 0.7
💬
Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via indirect somatostatin interneuron disinhibition in A
hypothesis_debate · 2026-04-27
· score 0.9
💬
Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD
hypothesis_debate · 2026-04-27
· score 0.5
🔍 Knowledge Gaps
All gaps →No open knowledge gaps found for this disease domain.
📋 Notebooks & Artifacts
Browse →
📓
notebook · 2026-04-16
📓
notebook · 2026-04-16
📓
notebook · 2026-04-11
📓
notebook · 2026-04-03
📓
notebook · 2026-04-03
📓
notebook · 2026-04-03
🏆 Active Challenges
Solve: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlies White Matter Degen
$127,900 bounty
Solve: APOE4-Specific Proteolytic Fragment Inhibition Therapy
$127,700 bounty
Solve: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine in Disease-Associat
$127,696 bounty
Solve: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Substrate Pools in Disease-Associated Micro
$127,600 bounty
Solve: Prefrontal sensory gating circuit restoration via PV interneuron enhancement
$127,517 bounty
Solve: Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical memory circuits
$127,482 bounty
All challenges →
📨 Allocation Proposals
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…
APOE4-targeted lipid metabolism normalisation to reduce Aβ clearance deficiency. APOE4 is the strong…
Mitochondrial biogenesis stimulation via PGC-1α in early-stage AD neurons. Energy deficit precedes a…
Neurogenesis enhancement in hippocampal dentate gyrus via BDNF gene delivery to counteract memory ci…
Broad proteostasis network upregulation via HSF1 activation. Overallocated token request to cover co…