concept

ALX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

1Analyses

17Outgoing

3Incoming

0Experiments

1Debates

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💡 Concept Info

Name	ALX
Key Genes/Proteins	AMPK, Annexin A1, ANXA1
Related Pathways	AMPK-mTOR Pathway, NF-kB signaling, oxidative stress response, PI3K-AKT-mTOR signaling

Wiki Pages (1)

Knowledge base pages for this entity

Blarcamesine (ALX-001)

therapeutic · 2127 words

→

Pathway Diagram

graph TD
    ALX[ALX]
    ALX -->|mediates| Anti_inflammatory_Response[Anti-inflammatory Response]
    ALX -->|binds| ANXA1[ANXA1]
    ALX -->|activates| AMPK_mTOR_Pathway[AMPK-mTOR Pathway]
    ALX -->|interacts| Annexin_A1[Annexin A1]
    ALX -->|activates| SIRT1[SIRT1]
    ALX -->|regulates| pulmonary_endothelial_glycocal[pulmonary endothelial glycocalyx]
    ALX -->|participates in| oxidative_stress_response[oxidative stress response]
    ALX -->|regulates| stroke[stroke]
    ALX -->|regulates| AMPK[AMPK]
    PCTR1[PCTR1] -->|activates| ALX
    rapamycin[rapamycin] -->|targets| ALX
    benchmark_ot_ad_answer_key_ALX[benchmark_ot_ad_answer_key:ALX] -->|data_in| ALX

Outgoing (17)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ALX	data_in	dataset_row	0.00
Anti-inflammatory Response	mediates	process	0.87
ANXA1	binds	protein	0.85
Annexin A1	interacts_with	protein	0.80
SIRT1	activates	protein	0.80
pulmonary endothelial glycocalyx	regulates	process	0.80
AMPK-mTOR Pathway	activates	pathway	0.80
oxidative stress response	participates_in	pathway	0.70
AMPK	regulates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
stroke	regulates	disease	0.60
endothelial cells	expressed_in	cell_type	0.60
SIRT1	regulates	gene	0.60
AMPK	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.55
microglia	expressed_in	cell_type	0.55

Incoming (3)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ALX	data_in	dataset_row	0.00
PCTR1	activates	compound	0.80
rapamycin	targets	drug	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do SPM receptors undergo desensitization with chronic agonist treatment, prevent

pharmacology | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted receptor desensitization as a critical concern for SPM re

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning ALX in their description or question text

No additional research found