Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about 4EBP1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
The N-terminal region contains the minimal eIF4E-binding motif (YXXXXLΦ, where Φ represents a hydrophobic amino acid) that is essential for binding to eIF4E.
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| Gene Symbol | 4EBP1PROTEIN |
| Function | is a critical regulator of cap-dependent translation initiation in eukaryotic cells. |
| Subcellular Localization | </strong></td><td>Cytoplasm, nucleus</td></tr> |
| Amino Acids | 118 aa |
| Thr37 and Thr46 | Primary mTOR phosphorylation sites; these priming phosphorylations create docking sites for subsequent phosphorylation |
| Ser65 | Secondary site; phosphorylation here significantly reduces eIF4E binding affinity |
| Thr70 | Tertiary site; phosphorylation further stabilizes the dissociated state |
| Ser83 and Ser101 | Additional regulatory sites involved in cell cycle-dependent regulation 5 |
| Associated Diseases | neurodegeneration |
| Interactions | MTOR |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
4EBP1PROTEIN["4EBP1PROTEIN"]
neurodegeneration["neurodegeneration"]
4EBP1PROTEIN -->|"implicated_in"| neurodegeneration
style 4EBP1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| proteins-4e-bp1-protein | describes | wiki | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning 4EBP1PROTEIN in their description or question text
No additional research found