Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about β-AMYLOID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | β-AMYLOID |
graph TD
__AMYLOID[β-AMYLOID]
__AMYLOID -->|causes| Retinal_Degeneration[Retinal Degeneration]
__AMYLOID -->|involved_in| Ocular_Glymphatic_System[Ocular Glymphatic System]
__AMYLOID -->|activates| NLRP3[NLRP3]
__AMYLOID -->|implicated in| Alzheimer_s_Disease[Alzheimer's Disease]
__AMYLOID -->|interacts| Microglia[Microglia]
__AMYLOID -->|interacts| microglia[microglia]
Cerebrospinal_Fluid[Cerebrospinal Fluid] -->|mediates| __AMYLOID
TREM2[TREM2] -->|binds| __AMYLOID
Optic_Nerve[Optic Nerve] -->|mediates| __AMYLOID
Perivascular_Space[Perivascular Space] -->|involved_in| __AMYLOID
microglia -->|interacts| __AMYLOID
APP[APP] -->|causes| __AMYLOID
transcription_factors[transcription factors] -->|regulates| __AMYLOID| Target | Relation | Type | Str |
|---|---|---|---|
| Retinal Degeneration | causes | phenotype | 0.95 |
| Ocular Glymphatic System | involved_in | process | 0.90 |
| NLRP3 | activates | gene | 0.85 |
| Cognitive Decline | contributes_to | phenotype | 0.80 |
| Alzheimer's Disease | implicated_in | disease | 0.80 |
| PYRAMIDAL NEURONS | accumulates_intraneuronally | cell_type | 0.80 |
| Microglia | interacts_with | cell_type | 0.70 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| microglia | interacts_with | cell_type | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | associated_with | disease | 0.95 |
| sleep | associated_with | process | 0.95 |
| TREM2 | binds | gene | 0.90 |
| Cerebrospinal Fluid | mediates | compound | 0.90 |
| Optic Nerve | mediates | cell_type | 0.85 |
| Perivascular Space | involved_in | cell_type | 0.85 |
| microglia | interacts_with | cell_type | 0.70 |
| MAPT | enhances | gene | 0.70 |
| C1Q | associated_with | gene | 0.70 |
| APP | causes | gene | 0.60 |
| transcription factors | regulates | protein_class | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Choli | 0.769 | - | Do β-amyloid plaques and neurofibrillary |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| α7nAChR activation in AT2 cells promotes alveolar regeneration through WNT7B sig [PMID:37410546] | Unknown | JCI Insight | 2023 | 0 |
| Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresse [PMID:30185628] | Unknown | Cancer discovery | 2019 | 0 |
| CHRNA7 Deletions are Enriched in Risperidone-Treated Children and Adolescents. [PMID:28817303] | Gillentine Madelyn A; White Janson J; Gr | Journal of child and adolescen | 2017 | 0 |
| Analysis of CHRNA7 rare variants in autism spectrum disorder susceptibility. [PMID:25655306] | Unknown | Am J Med Genet A | 2015 | 0 |
| The human clinical phenotypes of altered CHRNA7 copy number. [PMID:26095975] | Unknown | Biochem Pharmacol | 2015 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning β-AMYLOID in their description or question text
No additional research found