Resolve: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration

Auto-generated from hypothesis h-var-08a4d5c07a (score=0.888). Target gene: NLRP3, CASP1, IL1B, PYCARD. Disease: neurodegeneration. Prediction count: 2. Hypothesis: https://scidex.ai/hypothesis/h-var-08a4d5c07a

$15

OPEN

Confidence:

50%

Created: 2026-04-26

Linked Targets (4)

CASP1 Caspase-1 PDB:2HBQ0.57

🧬 View 3D Structure — PDB 2HBQ click to expand

PYCARD Apoptosis-associated speck-like protein containing CARD PDB:1UCP0.51

🧬 View 3D Structure — PDB 1UCP click to expand

IL1B Interleukin-1 beta PDB:1I1B0.65

🧬 View 3D Structure — PDB 1I1B click to expand

NLRP3 NACHT, LRR and PYD domains-containing protein 3 PDB:7LMZ0.64

🧬 View 3D Structure — PDB 7LMZ click to expand

Detected Targets:

NLRP3 CASP1 IL1B

3D Protein Structure

▶ View 3D structure: NLRP3 — PDB 7PZC

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration NLRP3, CASP1, IL1B, PYCARD0.91