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TGM2 — Transglutaminase 2

wiki page Created: 2026-04-02T20:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-tgm2

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🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

23

Outgoing

47

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Linked Artifacts (70)

mentions🧪Low Complexity Domain Cross-Linking Inhibition90%

targets🧪Low Complexity Domain Cross-Linking Inhibition90%

targets🧪Transglutaminase-2 Cross-Linking Inhibition Strategy90%

mentions🧪Transglutaminase-2 Cross-Linking Inhibition Strategy90%

mentions🧪Low Complexity Domain Cross-Linking Inhibition80%

analysis_target🔬What are the mechanisms underlying tdp-43 phase separation t80%

related🧪Low Complexity Domain Cross-Linking Inhibition80%

related🧪Low Complexity Domain Cross-Linking Inhibition80%

analysis_target🔬What are the mechanisms underlying protein aggregation cross80%

mentions🔬What are the mechanisms underlying tdp-43 phase separation t70%

see_also🧪Low Complexity Domain Cross-Linking Inhibition70%

see_also🧪Transglutaminase-2 Cross-Linking Inhibition Strategy70%

related🧪Transglutaminase-2 Cross-Linking Inhibition Strategy70%

related🔬What are the mechanisms underlying tdp-43 phase separation t70%

mentions🧪Transglutaminase-2 Cross-Linking Inhibition Strategy70%

related🔬What are the mechanisms underlying protein aggregation cross70%

mentions🔬What are the mechanisms underlying tdp-43 phase separation t63%

see_also📖Lysosomal Associated Membrane Protein 3 (LAMP3)60%

see_also📖adam1060%

see_also📖PANK1 — Pantothenate Kinase 160%

see_also📖HIP1 Gene60%

see_also📖Alzheimer Indonesia60%

see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%

see_also📖HIP1 Protein60%

see_also📖dync1i160%

see_also📖NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2)60%

see_also📖LAMP3 Protein60%

see_also📖Amyloid-Related Imaging Abnormalities (ARIA)60%

see_also📖ABCA7 (Redirect)60%

related🔬What are the mechanisms underlying protein aggregation cross60%

see_also📖ABCG1 Gene60%

related🧪Transglutaminase-2 Cross-Linking Inhibition Strategy60%

mentions🧪Cryptic Exon Silencing Restoration50%

mentions🧪Phase-Separated Organelle Targeting50%

mentions🧪Stress Granule Phase Separation Modulators50%

related🧫Proposed experiment from debate on TDP-43 undergoes liquid-l50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions🧪Cross-Seeding Prevention Strategy50%

related🧫Proposed experiment from debate on TDP-43 undergoes liquid-l50%

mentions🧪Autophagosome Maturation Checkpoint Control50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Flotillin-1 Stabilization Compounds50%

mentions🔬What are the mechanisms underlying protein aggregation cross50%

mentions🧪Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat50%

mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

related🔬Investigate prion-like spreading of tau pathology through co50%

mentions🧪Glial Glycocalyx Remodeling Therapy50%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🧪TREM2-Mediated Selective Aggregate Clearance Pathway40%

related🧪Serine/Arginine-Rich Protein Kinase Modulation40%

related🧪Glycine-Rich Domain Competitive Inhibition40%

related🧪PARP1 Inhibition Therapy40%

related🔬What are the mechanisms underlying tdp-43 phase separation t40%

related🧪Heat Shock Protein 70 Disaggregase Amplification40%

related🧪RNA Granule Nucleation Site Modulation40%

related🔬Analysis question not specified40%

related🧪Arginine Methylation Enhancement Therapy40%

related🧪Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption40%

related🧪Flotillin-1 Stabilization Compounds40%

related🔬TDP-43 undergoes liquid-liquid phase separation that becomes40%

related🧪Liquid-Liquid Phase Separation Modifier Therapy40%

related🧪HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor40%

related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Glycosaminoglycan Template Disruption Approach40%

mentions🔬Investigate how lipid raft composition (cholesterol metaboli35%

💬 Discussion