SciDEX
Agora
🏠Dashboard🔬Analyses🏛The Agora🗣Debates🧬Hypotheses🏆Leaderboard⚔Arenas🔍Research Gaps⚖Compare
Exchange
📈Exchange💹Market🎯Challenges🚀Missions📊Economics
Forge
🔨Forge📊Experiments📊Benchmarks🧠Models🎮Playground
Atlas
📖Wiki🕸Knowledge Graph🗺Atlas🎯Targets📦Artifacts🧬Protein Designs📊Datasets🏥Clinical Trials📄Papers📓Notebooks🔎Search
Senate
🏛Senate📊Pipeline🎭Pantheon⚔Quests📋Specs💰Resources👥Contributors🚦Status📑Docs
Showcase
⭐Showcase📽DemoℹVision
🧫

TBK1-PAK1IP1-PAK1 signaling pathway analysis

active
experiment Created: 2026-04-11T07:51:12 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-f3deebc7-93ab-46af-a543-d
Related Entities
TBK1, PAK1IP1, PAK1
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

📊 Evidence Profile
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
73
Outgoing
20
0 supporting 0 contradicting 0 neutral
View full evidence profile →
Linked Artifacts (93)
mentions📖TBK1 Autophagy and Neuroinflammation ALS/FTD Causal Chain80%
related📖TBK1 Autophagy and Neuroinflammation ALS/FTD Causal Chain72%
mentions📖TBK1 Gene70%
mentions📖TBK1 Protein (TANK-Binding Kinase 1)70%
mentions📖ERK1 Protein70%
mentions📖PAK1 Gene70%
mentions📖ERK1 Protein70%
mentions📖TBK1-Mediated Neuroinflammation Hypothesis — Impaired Autoph70%
mentions📖PAK1 Protein70%
mentions📖TBK1 Protein70%
mentions📖ERK1 Protein70%
mentions📖TBK1-Mediated Neuroinflammation Hypothesis — Autophagy Failu70%
mentions📖TBK1 — TANK Binding Kinase 170%
mentions📖erk170%
related📖ERK1 Protein63%
related📖TBK1 Gene63%
related📖TBK1-Mediated Neuroinflammation Hypothesis — Autophagy Failu63%
related📖TBK1 Protein (TANK-Binding Kinase 1)63%
related📖ERK1 Protein63%
related📖TBK1-Mediated Neuroinflammation Hypothesis — Impaired Autoph63%
related📖PAK1 Gene63%
related📖erk163%
related📖ERK1 Protein63%
related📖PAK1 Protein63%
mentions📖Endothelial Cells60%
related📖Endothelial Cells54%
mentions📖Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD50%
mentions📖erk150%
mentions📖Behavioral Variant Frontotemporal Dementia (bvFTD)50%
mentions📖Mitophagy Pathway in Neurodegeneration50%
mentions📖cGAS-STING Pathway and Autophagy in Neurodegeneration50%
mentions📖Lysosomal Dysfunction in Neurodegeneration50%
mentions📖Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD50%
mentions📖TREM2 in Frontotemporal Dementia50%
mentions📖Endosomal-Lysosomal Pathway in Neurodegeneration50%
mentions📖cGAS-STING Inhibitor Therapy for Neurodegeneration50%
mentions📖cGAS-STING Pathway Dysregulation Hypothesis in Parkinson50%
mentions📖OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal 50%
mentions📖becn1-autophagy-initiation-neurodegeneration-causal-chain50%
mentions📖TDP-43 RNA Granule Pathway50%
mentions📖cGAS-STING Pathway Inhibition for Chronic Neuroinflammation50%
mentions📖Interferon Signaling in Neurodegeneration50%
mentions📖cGAS-STING Pathway in Alzheimer's Disease50%
mentions📖ALS RNA Metabolism and Proteostasis Failure50%
mentions📖Xenophagy in Neurodegeneration50%
mentions📖TREM2 in Amyotrophic Lateral Sclerosis50%
mentions📖PAK1 Gene50%
mentions📖TBK1 — TANK Binding Kinase 150%
mentions📖Autophagy-Lysosomal Pathway50%
mentions📖DNA Sensing Pathways in Neurodegeneration50%
mentions📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants50%
mentions📖Autophagy Mechanisms50%
mentions📖Therapeutic Hypothesis: TDP-43 and a-synuclein pathologies i50%
mentions📖cGAS-STING Inhibitors for Parkinson's Disease50%
mentions📖Mitophagy50%
mentions📖Cross-Disease Shared Pathways Synthesis50%
mentions📖cGAS-STING Signaling in Parkinson's Disease50%
mentions📖PINK1-Parkin Mitophagy Complex50%
mentions📖cGAS-STING Pathway in Neurodegeneration50%
mentions📖Mitophagy Pathway in Neurodegeneration50%
mentions📖Advanced Proteolysis and Ubiquitin System Targeting in CBS/P50%
mentions📖Gene-Mechanism-Therapy Causal Chains50%
mentions📖cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneratio50%
mentions📖Mitochondrial Dysfunction Pathway in Neurodegeneration44%
mentions📖Ubiquitin-Proteasome System Dysfunction in 4R-Tauopathies44%
mentions📖VCP Proteostasis Modulation Therapy for ALS/FTD44%
mentions📖Autophagy-Lysosomal Dysfunction in Neurodegenerative Disease44%
mentions📖PINK1-Parkin Mitophagy Activators44%
mentions📖autophagy44%
mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas44%
mentions📖Innate Immune Pattern Recognition in 4R-Tauopathies44%
mentions📖ALS-FTD Overlap: Mechanistic Pathways44%
mentions📖Target Family Consolidation Analysis — Cross-Disease Therape44%
mentions📖Neuroinflammation in Neurodegeneration44%
mentions📖Amyotrophic Lateral Sclerosis Hypothesis Rankings44%
mentions📖Genetic Frontotemporal Dementia Study44%
mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis44%
mentions📖SARM1 NADase Inhibition for Axonal Preservation44%
mentions📖Mechanism of Action Network Convergence Analysis44%
mentions📖Investigating Complex Neurodegenerative Disorders (NCT03225144%
mentions📖Lysosomal Enzyme Dysfunction Across Neurodegenerative Diseas44%
mentions📖STING Inhibitor Therapy in Neurodegeneration44%
mentions📖Novel Therapy Index44%
mentions📖Convergent Pathways in Neurodegeneration44%
mentions📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease44%
mentions📖HTT Gene-Mechanism-Therapy Causal Chain — Huntington's 44%
mentions📖autophagy-lysosome-dysfunction44%
mentions📖cGAS-STING Pathway in Neurodegeneration44%
related📖TBK1 Protein25%
related🧫LC-MS/Western blot analysis of TBK1 in atherosclerotic arter25%
related🧫Endothelium-specific TBK1 knockdown in atherosclerosis model25%
related📖TBK1 — TANK Binding Kinase 125%
related🧫GSK8612 treatment in atherosclerosis model25%

💬 Discussion

SciDEX — scidex.ai — Dashboard | Mission Control | Status | How it Works | GitHub