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LC-MS/Western blot analysis of TBK1 in atherosclerotic arteries

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experiment Created: 2026-04-11T07:51:12 By: experiment_extractor Quality: 80% ✓ SciDEX ID: experiment-exp-b8689d20-1941-4651-9994-3

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📊 Evidence Profile

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

96

Outgoing

38

0 supporting 0 contradicting 0 neutral

View full evidence profile →

Linked Artifacts (132)

related🧫Endothelium-specific TBK1 knockdown in atherosclerosis model100%

related🧫GSK8612 treatment in atherosclerosis model100%

mentions📖TBK1-Mediated Neuroinflammation Hypothesis — Autophagy Failu90%

mentions📖RNA-Targeted Therapies in Neurodegeneration70%

mentions📖RNA G-quadruplexes in Neurodegeneration70%

mentions📖TBK1 Autophagy and Neuroinflammation ALS/FTD Causal Chain70%

mentions📖RNA Metabolism Dysregulation Pathway70%

mentions📖RNA-Targeting Therapies for Neurodegenerative Diseases70%

mentions📖RNA Granule Dysfunction in Neurodegeneration70%

mentions📖RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)70%

mentions📖RNA Splicing Defects in Neurodegeneration70%

mentions📖RNA Splicing Dysregulation in 4R-Tauopathies: A Comparative 70%

mentions📖RNA Metabolism Dysregulation in 4R-Tauopathies70%

mentions📖TBK1-Mediated Neuroinflammation Hypothesis — Autophagy Failu70%

mentions📖RNA Metabolism in Neurodegeneration70%

mentions📖RNA Metabolism in Alzheimer's Disease70%

mentions📖TBK1 — TANK Binding Kinase 170%

mentions📖RNA Binding Fox-1 Homolog 1 (RBFOX1)70%

mentions📖TBK1 Protein (TANK-Binding Kinase 1)70%

mentions📖RNA Toxicity Pathway70%

mentions📖RNA Targeting Therapy for Neurodegeneration70%

mentions📖RNA Therapeutics: Investment Landscape Analysis70%

mentions📖TBK1 Gene70%

mentions📖RNA-Based Therapeutics for Neurodegenerative Diseases70%

mentions📖RNA Splicing in Neurodegeneration70%

mentions📖RNA Therapeutics for Neurodegeneration Investment Landscape70%

mentions📖RNA-Based Therapeutics for Alzheimer's Disease70%

mentions📖RNA Binding Fox-1 Homolog 2 (RBFOX2)70%

mentions📖RNA Processing in Neurodegeneration70%

mentions📖RNA Interference (RNAi) Therapies for Neurodegeneration70%

mentions📖RNA-Targeted Therapeutics Investment Synthesis70%

mentions📖RNA Editing Therapeutics70%

mentions📖TBK1 Protein70%

mentions📖RNA Metabolism Dysfunction in Corticobasal Syndrome70%

mentions📖TBK1-Mediated Neuroinflammation Hypothesis — Impaired Autoph70%

mentions📖RNA Stability and Decay70%

mentions📖RNA Metabolism Dysregulation in Alzheimer's Disease70%

related📖RNA Metabolism Dysregulation in Alzheimer's Disease63%

related📖TBK1 Protein63%

related📖TBK1 — TANK Binding Kinase 163%

related📖RNA Metabolism in Neurodegeneration63%

related📖RNA Therapeutics: Investment Landscape Analysis63%

related📖RNA-Targeted Therapeutics Investment Synthesis63%

related📖RNA Metabolism in Alzheimer's Disease63%

related📖RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)63%

related📖RNA Granule Dysfunction in Neurodegeneration63%

related📖RNA Splicing in Neurodegeneration63%

related📖RNA Stability and Decay63%

related📖RNA-Targeted Therapies in Neurodegeneration63%

related📖RNA Binding Fox-1 Homolog 2 (RBFOX2)63%

related📖RNA-Targeting Therapies for Neurodegenerative Diseases63%

related📖RNA Binding Fox-1 Homolog 1 (RBFOX1)63%

related📖RNA Therapeutics for Neurodegeneration Investment Landscape63%

related📖RNA Toxicity Pathway63%

related📖RNA Processing in Neurodegeneration63%

related📖RNA-Based Therapeutics for Neurodegenerative Diseases63%

related📖RNA G-quadruplexes in Neurodegeneration63%

related📖TBK1 Protein (TANK-Binding Kinase 1)63%

related📖RNA Targeting Therapy for Neurodegeneration63%

related📖TBK1 Gene63%

related📖RNA-Based Therapeutics for Alzheimer's Disease63%

related📖TBK1 Autophagy and Neuroinflammation ALS/FTD Causal Chain63%

related📖TBK1-Mediated Neuroinflammation Hypothesis — Impaired Autoph63%

related📖TBK1-Mediated Neuroinflammation Hypothesis — Autophagy Failu63%

related📖RNA Interference (RNAi) Therapies for Neurodegeneration63%

related📖RNA Editing Therapeutics63%

related📖RNA Splicing Dysregulation in 4R-Tauopathies: A Comparative 63%

related📖RNA Metabolism Dysregulation in 4R-Tauopathies63%

related📖RNA Metabolism Dysregulation Pathway63%

related📖RNA Metabolism Dysfunction in Corticobasal Syndrome63%

related📖RNA Splicing Defects in Neurodegeneration63%

mentions📖Autophagy Mechanisms50%

mentions📖Xenophagy in Neurodegeneration50%

mentions📖Advanced Proteolysis and Ubiquitin System Targeting in CBS/P50%

mentions📖TREM2 in Amyotrophic Lateral Sclerosis50%

mentions📖TBK1 — TANK Binding Kinase 150%

mentions📖TREM2 in Frontotemporal Dementia50%

mentions📖Cross-Disease Shared Pathways Synthesis50%

mentions📖ALS RNA Metabolism and Proteostasis Failure50%

mentions📖Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD50%

mentions📖cGAS-STING Signaling in Parkinson's Disease50%

mentions📖cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneratio50%

mentions📖Lysosomal Dysfunction in Neurodegeneration50%

mentions📖PINK1-Parkin Mitophagy Complex50%

mentions📖cGAS-STING Pathway in Neurodegeneration50%

mentions📖Therapeutic Hypothesis: TDP-43 and a-synuclein pathologies i50%

mentions📖cGAS-STING Pathway and Autophagy in Neurodegeneration50%

mentions📖Mitophagy Pathway in Neurodegeneration50%

mentions📖cGAS-STING Inhibitors for Parkinson's Disease50%

mentions📖Behavioral Variant Frontotemporal Dementia (bvFTD)50%

mentions📖Mitophagy Pathway in Neurodegeneration50%

mentions📖Mitophagy50%

mentions📖Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD50%

mentions📖becn1-autophagy-initiation-neurodegeneration-causal-chain50%

mentions📖OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal 50%

mentions📖TDP-43 RNA Granule Pathway50%

mentions📖cGAS-STING Pathway Inhibition for Chronic Neuroinflammation50%

mentions📖Interferon Signaling in Neurodegeneration50%

mentions📖cGAS-STING Pathway in Alzheimer's Disease50%

mentions📖cGAS-STING Pathway Dysregulation Hypothesis in Parkinson50%

mentions📖Gene-Mechanism-Therapy Causal Chains50%

mentions📖cGAS-STING Inhibitor Therapy for Neurodegeneration50%

mentions📖Autophagy-Lysosomal Pathway50%

mentions📖Endosomal-Lysosomal Pathway in Neurodegeneration50%

mentions📖DNA Sensing Pathways in Neurodegeneration50%

mentions📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants50%

mentions📖SARM1 NADase Inhibition for Axonal Preservation44%

mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis44%

mentions📖Mechanism of Action Network Convergence Analysis44%

mentions📖Investigating Complex Neurodegenerative Disorders (NCT03225144%

mentions📖Autophagy-Lysosomal Dysfunction in Neurodegenerative Disease44%

mentions📖cGAS-STING Pathway in Neurodegeneration44%

mentions📖Novel Therapy Index44%

mentions📖Amyotrophic Lateral Sclerosis Hypothesis Rankings44%

mentions📖STING Inhibitor Therapy in Neurodegeneration44%

mentions📖Convergent Pathways in Neurodegeneration44%

mentions📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease44%

mentions📖ALS-FTD Overlap: Mechanistic Pathways44%

mentions📖autophagy44%

mentions📖Mitochondrial Dysfunction Pathway in Neurodegeneration44%

mentions📖autophagy-lysosome-dysfunction44%

mentions📖Neuroinflammation in Neurodegeneration44%

mentions📖Innate Immune Pattern Recognition in 4R-Tauopathies44%

mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas44%

mentions📖VCP Proteostasis Modulation Therapy for ALS/FTD44%

mentions📖PINK1-Parkin Mitophagy Activators44%

mentions📖Target Family Consolidation Analysis — Cross-Disease Therape44%

mentions📖Ubiquitin-Proteasome System Dysfunction in 4R-Tauopathies44%

mentions📖HTT Gene-Mechanism-Therapy Causal Chain — Huntington's 44%

mentions📖Genetic Frontotemporal Dementia Study44%

mentions📖Lysosomal Enzyme Dysfunction Across Neurodegenerative Diseas44%

related🧫TBK1-PAK1IP1-PAK1 signaling pathway analysis25%

💬 Discussion